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Machine translation
1. (WO2001024781) GENE NECESSARY FOR STRIATAL FUNCTION, USES THEREOF, AND COMPOUNDS FOR MODULATING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/024781    International Application No.:    PCT/CA2000/001188
Publication Date: 12.04.2001 International Filing Date: 06.10.2000
Chapter 2 Demand Filed:    03.05.2001    
IPC:
A61K 31/00 (2006.01), A61K 31/4985 (2006.01), A61K 31/65 (2006.01), C12Q 1/68 (2006.01)
Applicants: NOVANEURON INC. [CA/CA]; 5859 University Avenue, Sir Charles Tupper Medical Bldg., Room 15D7, Halifax, Nova Scotia B3H 4H7 (CA) (For All Designated States Except US).
ROBERTSON, Harold, A. [CA/CA]; (CA) (For US Only).
DENOVAN-WRIGHT, Eileen, M. [CA/CA]; (CA) (For US Only)
Inventors: ROBERTSON, Harold, A.; (CA).
DENOVAN-WRIGHT, Eileen, M.; (CA)
Agent: HELLER, David, J.; Ridout & Maybee, One Queen Street East, Suite 2400, Toronto, Ontario M5C 3B1 (CA)
Priority Data:
2,285,690 07.10.1999 CA
60/158,043 07.10.1999 US
60/217,765 12.07.2000 US
Title (EN) GENE NECESSARY FOR STRIATAL FUNCTION, USES THEREOF, AND COMPOUNDS FOR MODULATING SAME
(FR) GENE NECESSAIRE A LA FONCTION STRIATALE, SES APPLICATIONS ET COMPOSES PERMETTANT DE MODULER CE GENE
Abstract: front page image
(EN)PDE10A, a gene that is normally highly expressed in mammalian striatum and elsewhere, has been found to decrease in expression during the development of CAG repeat disorders such as Huntington's disease. The invention teaches a method for detecting the presence of or the predisposition for a CAG repeat disorder. Compounds which modulate CAG repeat disorders and their uses are taught. Methods for screening for further compounds to modulate CAG repeat disorders are also taught.
(FR)L'invention concerne un gène, PDE10A, qui est normalement fortement exprimé dans le striatum mammifère et ailleurs. L'expression de ce gène diminue pendant le développement de troubles liés à la répétition du triplet CAG tels que le maladie de Huntington. L'invention concerne un procédé de détection de la présence ou de la prédisposition pour l'apparition d'un trouble lié à la répétition du triplet CAG. Font aussi l'objet de cette invention des composés qui modulent les troubles liés à la répétition du triplet CAG et leurs applications, ainsi que des procédés de criblage d'autres composés de manière à moduler les troubles liés à la répétition du triplet CAG.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)