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1. (WO2001023613) HUMAN RNASE H AND OLIGONUCLEOTIDE COMPOSITIONS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/023613    International Application No.:    PCT/US2000/026729
Publication Date: 05.04.2001 International Filing Date: 29.09.2000
Chapter 2 Demand Filed:    27.04.2001    
IPC:
C07H 21/00 (2006.01), C12N 9/22 (2006.01), C12N 15/11 (2006.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 2292 Faraday Avenue, Carlsbad, CA 92008 (US) (For All Designated States Except US).
CROOKE, Stanley, T. [US/US]; (US) (For US Only).
LIMA, Walter, F. [US/US]; (US) (For US Only).
WU, Hongjiang [CN/US]; (US) (For US Only).
MANOHARAN, Muthiah [US/US]; (US) (For US Only)
Inventors: CROOKE, Stanley, T.; (US).
LIMA, Walter, F.; (US).
WU, Hongjiang; (US).
MANOHARAN, Muthiah; (US)
Agent: CALDWELL, John, W.; Woodcock Washburn Kurtz Mackiewicz & Norris LLP, 46th floor, One Liberty Place, Philadelphia, PA 19103 (US)
Priority Data:
09/409,926 30.09.1999 US
Title (EN) HUMAN RNASE H AND OLIGONUCLEOTIDE COMPOSITIONS THEREOF
(FR) RNASE H HUMAINE ET COMPOSITIONS NUCLEOTIDIQUES CORRESPONDANTES
Abstract: front page image
(EN)The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
(FR)L'invention concerne des oligonucléotides qui peuvent s'utiliser en tant que substrat pour la RNase H humaine de type 2. Elle concerne aussi des procédés pour utiliser ces oligonucléotides pour améliorer les thérapies à oligonucléotides antisens.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)