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1. (WO2001022962) ANTI-HYPERCHOLESTEROLEMIC DRUG COMBINATION

Pub. No.:    WO/2001/022962    International Application No.:    PCT/US2000/026414
Publication Date: Apr 5, 2001 International Filing Date: Sep 26, 2000
IPC: A61K 31/335
A61K 31/366
A61K 31/44
A61K 45/06
Applicants: MERCK & CO., INC.
CHAO, Yu-Sheng
Inventors: CHAO, Yu-Sheng
Title: ANTI-HYPERCHOLESTEROLEMIC DRUG COMBINATION
Abstract:
This invention provides a drug combination comprised of an HMG-CoA reductase inhibitor with an ACAT inhibitor in synergistic therapeutically effective amounts, which is useful for reducing cholesterol synthesis, lowering plasma LDL cholesterol levels and lowering plasma triglyceride levels. Profound synergy can be achieved only when the ACAT inhibitor is administered in low dosage amounts, above which the beneficial synergistic effects diminish and disappear.