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1. (WO2001022811) TRANSGENIC ANIMAL EXPRESSING A MULTIPLE MUTATED FORM OF PRESENILIN 1

Pub. No.:    WO/2001/022811    International Application No.:    PCT/FR2000/002623
Publication Date: Apr 5, 2001 International Filing Date: Sep 22, 2000
IPC: C07K 14/47
C12N 15/85
Applicants: AVENTIS PHARMA S.A.
ECKERT, Anne
MULLER, Walter
CZECH, Christian
PRADIER, Laurent
TREMP, Gunter
Inventors: ECKERT, Anne
MULLER, Walter
CZECH, Christian
PRADIER, Laurent
TREMP, Gunter
Title: TRANSGENIC ANIMAL EXPRESSING A MULTIPLE MUTATED FORM OF PRESENILIN 1
Abstract:
The invention concerns the field of transgenic animal models and more particularly, animal models of Alzheimer disease. The invention relates to a transgenic animal expressing a multiple mutated form of presenilin 1 and enabling to detect an apoptotic phenomenon in a renewable peripheral tissue.