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1. (WO2001016300) METHOD OF IDENTIFYING INHIBITORS OF CDC25

Pub. No.:    WO/2001/016300    International Application No.:    PCT/US2000/023473
Publication Date: Fri Mar 09 00:59:59 CET 2001 International Filing Date: Sat Aug 26 01:59:59 CEST 2000
IPC: A61K 38/00
C07K 5/10
C07K 5/107
C12N 9/16
Applicants: BASF AKTIENGESELLSCHAFT
GPC BIOTECH INC.
TAYLOR, Neil, R.
BORHANI, David
EPSTEIN, David
RUDOLPH, Johannes
RITTER, Kurt
FUJIMORI, Taro
ROBINSON, Simon
ECKSTEIN, Jens
HAUPT, Andreas
WALKER, Nigel
DIXON, Richard, W.
CHOQUETTE, Deborah
BLANCHARD, Jill
KLUGE, Arthur
PAL, Kollol
BOCKOVICH, Nicholas
COME, Jon
HEDIGER, Mark
Inventors: TAYLOR, Neil, R.
BORHANI, David
EPSTEIN, David
RUDOLPH, Johannes
RITTER, Kurt
FUJIMORI, Taro
ROBINSON, Simon
ECKSTEIN, Jens
HAUPT, Andreas
WALKER, Nigel
DIXON, Richard, W.
CHOQUETTE, Deborah
BLANCHARD, Jill
KLUGE, Arthur
PAL, Kollol
BOCKOVICH, Nicholas
COME, Jon
HEDIGER, Mark
Title: METHOD OF IDENTIFYING INHIBITORS OF CDC25
Abstract:
The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.