WO2001010462 TREATMENT OF PATIENTS HAVING NON-HODGKINS LYMPHOMA WITH BONE MARROW INVOLVEMENT WITH ANTI-CD20 ANTIBODIES

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Publication Number WO/2001/010462

Publication Date 15.02.2001

International Application No. PCT/US2000/040459

International Filing Date 25.07.2000

Chapter 2 Demand Filed 06.03.2001

IPC

CPC

Applicants

IDEC PHARMACEUTICALS CORPORATION [US]/[US] (AllExceptUS)
RASTETTER, William, H. [US]/[US] (UsOnly)

Inventors

RASTETTER, William, H.

Agents

TESKIN, Robin, L.

Priority Data

60/148,287

11.08.1999

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) TREATMENT OF PATIENTS HAVING NON-HODGKINS LYMPHOMA WITH BONE MARROW INVOLVEMENT WITH ANTI-CD20 ANTIBODIES

(FR) TRAITEMENT POUR PATIENTS ATTEINT D'UN LYMPHOME DIFFERENT DE LA MALADIE DE HODGKINS ET QUI TOUCHE LA MOELLE OSSEUSE, AVEC DES ANTICORPS ANTI-CD20

Abstract

(EN) This invention relates to methods of reducing bone marrow involvement in B cell lymphoma patients prior to radioimmunotherapy by administering monoclonal antibodies which target cancerous B cells.

(FR) La présente invention concerne des techniques permettant de réduire les cellules B cancéreuses de la moelle osseuse chez un patient atteint d'un lymphome B avant une radio-immunothérapie par l'administration d'anticorps monoclonaux qui ciblent les cellules B cancéreuses.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
505	comprising antibodies

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1. WO2001010462 - TREATMENT OF PATIENTS HAVING NON-HODGKINS LYMPHOMA WITH BONE MARROW INVOLVEMENT WITH ANTI-CD20 ANTIBODIES

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
20	characterized by taxonomic origin
24	containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
20	characterized by taxonomic origin
24	containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered