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1. WO2001010392 - COMPOSITION FOR RESTORING DEFECTS IN CALCIFIED TISSUES

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Publication Number WO/2001/010392
Publication Date 15.02.2001
International Application No. PCT/GB2000/003015
International Filing Date 04.08.2000
Chapter 2 Demand Filed 02.03.2001
IPC
A61K 6/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
02Use of preparations for artificial teeth, for filling or for capping teeth
06Use of inorganic cements
A61K 8/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
19containing inorganic ingredients
22Peroxides; Oxygen; Ozone
A61Q 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastes; Mouth rinses
CPC
A61K 6/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
15Compositions characterised by their physical properties
17Particle size
A61K 6/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
20Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
A61K 6/69
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
60comprising organic or organo-metallic additives
69Medicaments
A61K 6/77
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
70comprising inorganic additives
71Fillers
77Glass
A61K 6/807
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
80Preparations for artificial teeth, for filling teeth or for capping teeth
802comprising ceramics
807comprising magnesium oxide
A61K 6/816
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6Preparations for dentistry
80Preparations for artificial teeth, for filling teeth or for capping teeth
802comprising ceramics
816comprising titanium oxide
Applicants
  • BLOCK DRUG COMPANY, INC. [US]/[US]
  • WHALLEY, Kevin [GB]/[GB] (SD)
Inventors
  • DODD, Gregory, P.
  • HALECKY, Alan, A.
  • MARKOWITZ, Kenneth, J.
Agents
  • ABLEWHITE, Alan, James
Priority Data
09/419,51418.10.1999US
60/147,43805.08.1999US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITION FOR RESTORING DEFECTS IN CALCIFIED TISSUES
(FR) COMPOSITION DESTINEE A REPARER DES DEFAUTS DANS DES TISSUS CALCIFIES
Abstract
(EN) A composition for restoring defects in calcified tissues comprises an amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen. Said agent may be selected from the group consisting of : a) a reaction product of an organic silicate source and a source of calcium; b) a calcium containing hydrolysis product of tetraethylorthosilicate; c) a calcium containing silica sol-gel; d) a binary calcium oxide and silicate precipitated material; e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of soluble calcium source and a silicate solution. A process for producing the amorphous bioactive particulate consists essentially of adding a sufficient amount of a solution of a soluble calcium source to a solution of a silicate or silicate precursor to cause a precipitation of calcium-containing silicate particulate.
(FR) L'invention concerne une composition destinée à réparer des défauts dans des tissus calcifiés, qui comprend une substance particulaire bioactive amorphe constitué essentiellement de calcium, de silicium et d'oxygène. Cet agent peut être sélectionné dans le groupe constitué par: a) un produit réactionnel d'une source de silicate organique et d'une source de calcium; b) un produit hydrolytique à base de calcium d'un tétraéthylorthosilicate; c) un sol-gel de silice contenant du calcium; d) une matière précipitée binaire à base d'oxyde de calcium et de silicate; e) un analogue synthétique d'un silicate de calcium naturel de type wollastonite; et f) un produit réactionnel précipité d'une source de calcium soluble et d'une solution de silicate. Un procédé de production d'une substance particulaire bioactive amorphe consiste essentiellement à ajouter une quantité suffisante d'une solution d'une source de calcium soluble à une solution d'un silicate ou d'un précurseur de silicate, afin de provoquer une précipitation de ladite substance particulaire de silicate à base de calcium.
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