WO2001009089 PROCESS FOR THE PREPARATION OF ISOTRETINOIN

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Publication Number WO/2001/009089

Publication Date 08.02.2001

International Application No. PCT/IB2000/001020

International Filing Date 24.07.2000

Chapter 2 Demand Filed 23.02.2001

IPC

CPC

Applicants

RANBAXY LABORATORIES LIMITED [IN]/[IN] (AllExceptUS)
SALMAN, Mohammad [IN]/[IN] (UsOnly)
KAUL, Vijay, Kumar [IN]/[IN] (UsOnly)
BABU, J., Suresh [IN]/[IN] (UsOnly)
KUMAR, Naresh [IN]/[IN] (UsOnly)

Inventors

SALMAN, Mohammad
KAUL, Vijay, Kumar
BABU, J., Suresh
KUMAR, Naresh

Common Representative

RANBAXY LABORATORIES LIMITED

Priority Data

09/467,201		20.12.1999		US
1037/DEL/99		30.07.1999		IN

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) PROCESS FOR THE PREPARATION OF ISOTRETINOIN

(FR) PROCEDE DE PREPARATION D'ISOTRETINOINE

Abstract

(EN) The present invention relates to a process for the preparation of 13-cis isomer of Vitamin A acid, commonly known as isotretinoin, in a single step.

(FR) L'invention concerne un procédé de préparation, en une étape unique, de l'isomère 13-cis de la vitamine A acide, connu sous le nom d'isotrétinoïne.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
51	Preparation of carboxylic acids or their salts, halides, or anhydrides
347	by reactions not involving formation of carboxyl groups
353	by isomerisation; by change of size of the carbon skeleton

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
309	Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
32	having two double bonds between ring members or between ring members and non-ring members

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
51	Preparation of carboxylic acids or their salts, halides, or anhydrides
347	by reactions not involving formation of carboxyl groups
353	by isomerisation; by change of size of the carbon skeleton

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
309	Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
32	having two double bonds between ring members or between ring members and non-ring members

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
2601	Systems containing only non-condensed rings
12	with a six-membered ring
16	the ring being unsaturated

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1. WO2001009089 - PROCESS FOR THE PREPARATION OF ISOTRETINOIN

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
403	Derivatives of cyclohexane or of a cyclohexene ; or of cyclohexadiene; , having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene ; or cyclohexadiene; rings, e.g. vitamin A, beta-carotene, beta-ionone
20	having side-chains substituted by carboxyl groups ; or halides, anhydrides, or (thio)esters thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
403	Derivatives of cyclohexane or of a cyclohexene ; or of cyclohexadiene; , having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene ; or cyclohexadiene; rings, e.g. vitamin A, beta-carotene, beta-ionone
20	having side-chains substituted by carboxyl groups ; or halides, anhydrides, or (thio)esters thereof