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1. WO2001008421 - TABLET FOR PROGRAMMED DRUG RELEASE

Publication Number WO/2001/008421
Publication Date 01.02.2001
International Application No. PCT/IB2000/000988
International Filing Date 19.07.2000
Chapter 2 Demand Filed 15.02.2001
IPC
A61K 9/24 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
24Layered or laminated unitary dosage forms
A61K 9/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
A61K 9/46 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
46effervescent
CPC
A61K 9/0007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0007Effervescent
A61K 9/209
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2072characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
209containing drug in at least two layers or in the core and in at least one outer layer
A61K 9/2866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
286Polysaccharides, e.g. gums; Cyclodextrin
2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Applicants
  • JAGOTEC AG [CH]/[CH] (AllExceptUS)
  • GRENIER, Pascal [FR]/[FR] (UsOnly)
  • QUINTON, Jacques [FR]/[FR] (UsOnly)
  • RICCHI, Elisabeth [FR]/[FR] (UsOnly)
  • CHOPINET-CÔTE, Sandrine [FR]/[FR] (UsOnly)
  • VERGNAULT, Guy [FR]/[FR] (UsOnly)
  • ZIMMER, Robert [FR]/[FR] (UsOnly)
Inventors
  • GRENIER, Pascal
  • QUINTON, Jacques
  • RICCHI, Elisabeth
  • CHOPINET-CÔTE, Sandrine
  • VERGNAULT, Guy
  • ZIMMER, Robert
Agents
  • SCHMAUDER & PARTNER AG
Priority Data
99114237.327.07.1999EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TABLET FOR PROGRAMMED DRUG RELEASE
(FR) SYSTEME DE COMPRIME PHARMACEUTIQUE PERMETTANT DE LIBERER AU MOINS UNE SUBSTANCE ACTIVE AU COURS D'UNE PERIODE DE LIBERATION POSTERIEURE A UNE PERIODE DE NON LIBERATION
Abstract
(EN) The tablet system has a core-centered body covered with at least one couple of adjacent layers, one element fully enclosing the other. The enclosed element contains active substance and will, upon exposure to aqueous medium, undergo complete degradation during a period of release of active substance. The enclosing element is devoid of active substance and formulated to delay the latter's release from the enclosed element by a non-release period. To this effect, it has an intrinsic porosity that will remain constant while allowing and controlling the penetration of the aqueous medium towards the underlying enclosed element whose alteration will in turn cause a fragmentation of the enclosing element that will allow the aqueous medium to directly reach the enclosed element and provide for rapid establishment and progress to completion of the release of active substance. The layers may be made by spray-coating and/or pressing.
(FR) La présente invention concerne un système de comprimé qui présente un corps à noyau central couvert d'au moins deux couches adjacentes, un élément enfermant l'autre complètement. L'élément enfermé contient une substance active et, lorsque cet élément est exposé en milieu aqueux, il entreprend une dégradation complète pendant une période de libération de substance active. L'élément recouvrant est exempt de substance active et préparé de façon à retarder d'une période de non libération de substance active cette dernière libération de l'élément enfermé. Il présente, à cet effet, une porosité intrinsèque qui restera constante tout en permettant et en contrôlant la pénétration du milieu aqueux vers l'élément enfermé en dessous dont la modification entraînera à son tour une fragmentation de l'élément recouvrant, ce qui permettra au milieu aqueux d'atteindre directement l'élément enfermé et d'établir rapidement et complètement la libération de la substance active. On peut confectionner les couches par pulvérisation et/ou par pressage.
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