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1. (WO2001006015) NOVEL GLYCOSYL SULFOTRANSFERASES GST-4$g(a), GST-4$g(b), AND GST-6
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/006015 International Application No.: PCT/US2000/019741
Publication Date: 25.01.2001 International Filing Date: 19.07.2000
Chapter 2 Demand Filed: 03.01.2001
IPC:
A61K 38/00 (2006.01) ,C12N 9/10 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 12th floor 111 Franklin Street Oakland, CA 94607-5200, US
Inventors: ROSEN, Steven, D.; US
LEE, Jin, Kyu; US
HEMMERICH, Stefan; US
Agent: BORDEN, Paula, A.; Bozicevic, Field & Francis LLP Suite 200 200 Middlefield Road Menlo Park, CA 94025, US
Priority Data:
09/593,82813.06.2000US
60/144,69420.07.1999US
Title (EN) NOVEL GLYCOSYL SULFOTRANSFERASES GST-4$g(a), GST-4$g(b), AND GST-6
(FR) NOUVELLES GLYCOSYLSULFOTRANSFERASES GST-4$g(a), GST-4$g(b), ET GST-6
Abstract:
(EN) Novel glycosyl sulfotransferases (GST-4$g(a), GST-4$g(b), and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4$g(a), GST-4$g(b), and GST-6.
(FR) L'invention concerne de nouvelles glycosylsulfotransférases (GST-4$g(a), GST-4$g(b) et GST-6) et des polypeptides apparentés, ainsi que des compositions d'acides nucléiques les codant. Ces polypeptides et ces compositions d'acides nucléiques peuvent être mis en application dans une variété de domaines, y compris la recherche, le diagnostic et la détection d'agents thérapeutiques. Elle concerne également des procédés permettant d'inhiber des épisodes de fixation par l'intermédiaire de sélectine et des procédés servant à traiter des maladies associées à ceux-ci, en particulier par administration d'un inhibiteur d'au moins un de GST-4$g(a), GST-4$g(b) et GST-6.
Designated States: AU, CA, JP
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)