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1. (WO2001005998) FOLLISTATIN-3
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/005998    International Application No.:    PCT/US2000/019198
Publication Date: 25.01.2001 International Filing Date: 14.07.2000
Chapter 2 Demand Filed:    13.02.2001    
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/47 (2006.01)
Applicants: HUMAN GENOME SCIENCES, INC. [US/US]; 9410 Key West Avenue, Rockville, MD 20850 (US) (For All Designated States Except US).
DUAN, Roxanne, D. [US/US]; (US) (For US Only).
RUBEN, Steven, M. [US/US]; (US) (For US Only)
Inventors: DUAN, Roxanne, D.; (US).
RUBEN, Steven, M.; (US)
Agent: KENNY, Joseph, J.; Human Genome Sciences, Inc., 9410 Key West Avenue, Rockville, MD 20850 (US)
Priority Data:
60/144,088 16.07.1999 US
Abstract: front page image
(EN)The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
(FR)L'invention concerne une nouvelle protéine du type follistatine-3 appartenant à la famille des protéines liées aux inhibines. L'invention concerne notamment des molécules d'acide nucléique isolées codant la protéine follistatine-3 humaine. L'invention concerne également des polypeptides du type follistatine-3, ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant d'élaborer ces polypeptides. L'invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et des antagonistes vis-à-vis de l'activité de la follistatine-3. L'invention concerne enfin des procédés diagnostiques permettant de détecter les troubles liés à l'appareil reproducteur et les troubles de la régulation de la croissance et de la différenciation cellulaires, ainsi que des méthodes thérapeutiques destinées au traitement de ces deux catégories de troubles.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)