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1. (WO2001005998) FOLLISTATIN-3

Pub. No.:    WO/2001/005998    International Application No.:    PCT/US2000/019198
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Sat Jul 15 01:59:59 CEST 2000
IPC: A61K 38/00
A61K 48/00
C07K 14/47
Applicants: HUMAN GENOME SCIENCES, INC.
DUAN, Roxanne, D.
RUBEN, Steven, M.
Inventors: DUAN, Roxanne, D.
RUBEN, Steven, M.
Title: FOLLISTATIN-3
Abstract:
The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.