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1. (WO2001005988) LIVE RECOMBINANT VACCINE AGAINST AVIAN LEUKOSIS VIRUS USING A MAREK'S DISEASE VIRUS (MDV) VIRUS AS VECTOR

Pub. No.:    WO/2001/005988    International Application No.:    PCT/EP2000/007469
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Tue Jul 18 01:59:59 CEST 2000
IPC: A61K 39/00
A61K 39/21
C07K 14/15
C12N 15/869
Applicants: MERIAL SELECT, INC
AGRICULTURAL RESEARCH SERVICE
BUBLOT, Michel, Joseph, Marie
TAYLOR, Jill
FADLY, Aly
SMITH, Eugene
Inventors: BUBLOT, Michel, Joseph, Marie
TAYLOR, Jill
FADLY, Aly
SMITH, Eugene
Title: LIVE RECOMBINANT VACCINE AGAINST AVIAN LEUKOSIS VIRUS USING A MAREK'S DISEASE VIRUS (MDV) VIRUS AS VECTOR
Abstract:
Disclosed and claimed are recombinants or vectors including at least one nucleotide sequence encoding an immunogen or epitope or epitopic region thereof of avian leukosis virus of subgroup J, such as a recombinant MDV; for instance, a recombinant HVT. The recombinant or vector can express the immunogen, epitope or epitopic region; and, the immunogen can be the Env glycoprotein (gp85 and gp37) and/or the gag/pol proteins. The nucleotide sequence can be in the BamHI I or M fragment of the HVT genome; for instance in one of intergenic zones 1, 2, and 3 or in ORF UL55 or in ORF UL43. The nucleotide sequence can be under the control of a promoter such as a CMV-IE promoter. The recombinant can include at least one additional nucleotide sequence coding for an immunogen or epitope or epitopic region thereof of another avian leukosis of subgroup J and/or another avian pathogen. The recombinant can also include a nucleotide sequence encoding an immunomodulator such as an avian cytokine. Immunogenic, immunological or vaccine compositions containing inventive recombinants, as well as methods for immunizing fowl or for inducing an immunological response in birds, are also disclosed and claimed; and, kits for preparing such compositions are also envisioned.