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1. (WO2001005983) DSP-11 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE

Pub. No.:    WO/2001/005983    International Application No.:    PCT/US2000/019710
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Thu Jul 20 01:59:59 CEST 2000
IPC: C12N 9/16
Applicants: CEPTYR, INC.
LUCHE, Ralf, M.
WEI, Bo
Inventors: LUCHE, Ralf, M.
WEI, Bo
Title: DSP-11 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.