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1. (WO2001005983) DSP-11 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/005983    International Application No.:    PCT/US2000/019710
Publication Date: 25.01.2001 International Filing Date: 19.07.2000
Chapter 2 Demand Filed:    20.02.2001    
IPC:
C12N 9/16 (2006.01)
Applicants: CEPTYR, INC. [US/US]; 22215 - 26th Avenue Southeast, Bothell, WA 98021 (US) (For All Designated States Except US).
LUCHE, Ralf, M. [DE/US]; (US) (For US Only).
WEI, Bo [CN/US]; (US) (For US Only)
Inventors: LUCHE, Ralf, M.; (US).
WEI, Bo; (US)
Agent: ROSENMAN, Stephen, J.; Seed Intellectual Property Law Group PLLC, Suite 6300, 701 Fifth Avenue, Seattle, WA 98104-7092 (US).
GOWSHALL Jonathan V. FORRESTER & BOEHMERT; Forrester & Boehmert, Franz-Joseph-Str. 38, D- 80801 München (DE)
Priority Data:
60/144,557 20.07.1999 US
Title (EN) DSP-11 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE
(FR) PHOSPHATASE KINASE MAP A SPECIFICITE DUALE DSP-11
Abstract: front page image
(EN)Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
(FR)L'invention concerne des compositions et des procédés destinés au traitement de conditions liées à la prolifération, différenciation et survie cellulaires. Notamment, elle a trait à la phosphatase à spécificité duale DSP-11 et à des variants de polypeptides correspondants qui stimulent la déphosphorylation de substrats DSP-11. Les polypeptides peuvent être utilisés, par exemple, pour identifier des anticorps et d'autres agents qui inhibent l'activité DSP-11. Les polypeptides et les agents peuvent être utilisés pour moduler la prolifération, la différenciation et la survie cellulaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)