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1. (WO2001005978) FimH ADHESIN-BASED VACCINES

Pub. No.:    WO/2001/005978    International Application No.:    PCT/US2000/019402
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Sat Jul 15 01:59:59 CEST 2000
IPC: A61K 39/00
C07K 14/245
Applicants: MEDIMMUNE, INC.
Washington University
Inventors: HULTGREN, Scott, J.
LANGERMANN, Solomon
Title: FimH ADHESIN-BASED VACCINES
Abstract:
Purified polypeptides formed from amino acid sequences corresponding to domains derived from the adhesin protein, FimH, are disclosed. Also disclosed are compositions containing these novel polypeptides for use as vaccines and for generating specific antibodies for use in treatment and/or prevention of diseases, such as urinary tract infections, caused by bacteria of the family enterobacteriaceae, from which FimH is derived.