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1. (WO2001005791) NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/005791 International Application No.: PCT/HU2000/000078
Publication Date: 25.01.2001 International Filing Date: 13.07.2000
Chapter 2 Demand Filed: 27.11.2000
IPC:
C07D 209/96 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
96
Spiro-condensed ring systems
Applicants:
HÉJA, Gergely [HU/HU]; HU (UsOnly)
CSIKÓS, Éva [HU/HU]; HU (UsOnly)
ERŐSNÉ TAKÁCSY, Tünde [HU/HU]; HU (UsOnly)
GÖNCZI, Csaba [HU/HU]; HU (UsOnly)
HALÁSZ, Judit [HU/HU]; HU (UsOnly)
HERMECZ, István [HU/HU]; HU (UsOnly)
MAJLÁTH, Csilla [HU/HU]; HU (UsOnly)
NAGY, Lajos [HU/HU]; HU (UsOnly)
SÁNTÁNÉ CSUTOR, Andrea [HU/HU]; HU (UsOnly)
SÁROSI, Péter [HU/HU]; HU (UsOnly)
SIMON, Kálmán [HU/HU]; HU (UsOnly)
SZOMOR, Tiborné [HU/HU]; HU (UsOnly)
SZVOBODA, Györgyné [HU/HU]; HU (UsOnly)
SANOFI-SYNTHELABO [FR/FR]; 174, avenue de France F-75013 Paris, FR (AllExceptUS)
Inventors:
HÉJA, Gergely; HU
CSIKÓS, Éva; HU
ERŐSNÉ TAKÁCSY, Tünde; HU
GÖNCZI, Csaba; HU
HALÁSZ, Judit; HU
HERMECZ, István; HU
MAJLÁTH, Csilla; HU
NAGY, Lajos; HU
SÁNTÁNÉ CSUTOR, Andrea; HU
SÁROSI, Péter; HU
SIMON, Kálmán; HU
SZOMOR, Tiborné; HU
SZVOBODA, Györgyné; HU
Agent:
MIHÁLYI, György ; Sanofi-Synthelabo Tó u. 1-5 H-1045 Budapest, HU
Priority Data:
P 990237615.07.1999HU
Title (EN) NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS
(FR) NOUVELLE TECHNIQUE DE PREPARATION DE N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE ET SES SELS
Abstract:
(EN) The invention relates to a process for the preparation of a compound of formula (I) and the salts thereof by reacting the compound of formula (II) with the compound of formula (III), which comprises carrying out the reaction in dimethyl sulfoxide, at a temperature between 10 °C and 40 °C, preferably at room temperature and transforming the resulting base of formula (I), if desired, into its salt by a method known per se.
(FR) La présente invention concerne une technique de préparation d'un composé représenté par la formule (I) et de ses sels. Cette technique consiste à faire réagir le composé de formule (II) avec le composé de formule (III), ce qui implique de mettre en oeuvre cette réaction dans du sulfoxyde diméthylique, à une température située entre 10 °C et 40 °C, de préférence à température ambiante, et de transformer la base de formule (I) qui en résulte, le cas échéant, en ses sels par une technique connue en soi.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)