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1. (WO2001005770) BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/005770 International Application No.: PCT/JP2000/004687
Publication Date: 25.01.2001 International Filing Date: 12.07.2000
Chapter 2 Demand Filed: 26.12.2000
IPC:
C07D 235/26 (2006.01) ,C07D 235/28 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/12 (2006.01) ,C07D 403/04 (2006.01) ,C07D 405/04 (2006.01) ,C07D 405/12 (2006.01) ,C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
235
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02
condensed with carbocyclic rings or ring systems
04
Benzimidazoles; Hydrogenated benzimidazoles
24
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
26
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
235
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02
condensed with carbocyclic rings or ring systems
04
Benzimidazoles; Hydrogenated benzimidazoles
24
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
28
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
SAWADA, Kozo [JP/JP]; JP (UsOnly)
INOUE, Takayuki [JP/JP]; JP (UsOnly)
SAWADA, Yuki [JP/JP]; JP (UsOnly)
MIZUTANI, Tsuyoshi [JP/JP]; JP (UsOnly)
FUJISAWA PHARMACEUTICAL CO., LTD. [JP/JP]; 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541-8514, JP (AllExceptUS)
Inventors:
SAWADA, Kozo; JP
INOUE, Takayuki; JP
SAWADA, Yuki; JP
MIZUTANI, Tsuyoshi; JP
Agent:
NOGAWA, Shintaro; Minamimorimachi Park Bldg. 1-3, Nishitenma 5-chome Kita-ku Osaka-shi Osaka 530-0047, JP
Priority Data:
PQ 174721.07.1999AU
PQ 273009.09.1999AU
Title (EN) BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
(FR) DERIVES DE BENZIMIDAZOLONE ET LEUR UTILISATION COMME INHIBITEURS DE LA PHOSPHODIESTERASE
Abstract:
(EN) Compounds of formula (Ia) wherein Xa is CH or nitrogen, Ya is oxygen or sulfur, R1a and R2a are specific substituents, R3a, R4a and R5a are the same or different, hydrogen, halogen, cyano, lower alkoxy or lower-alkoxy-substituted aralkyl; or two of R3a, R4a and R5a may combine together to form lower alkylenedioxy, and m is 1 or 2, are useful as cGMP-PDE inhibitors.
(FR) La présente invention concerne des composés représentés par la formule générale et convenant comme inhibiteurs de la cGMP-PDE. En l'occurrence, Xa est CH ou azote. Ya est oxygène ou soufre. R1a et R2a sont des substituants spécifiques. R3a, R4a et R5a sont identiques ou différents, hydrogène, halogène, cyano, alcoxy inférieur ou aralkyle à substitution d'alcoxy inférieur. Mais il est également possible que deux des groupes R3a, R4a et R5a se combinent ensemble pour former un alkylènedioxy inférieur. Enfin, m vaut 1 ou 2.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)