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1. (WO2001005767) ORGANIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/005767 International Application No.: PCT/EP2000/006876
Publication Date: 25.01.2001 International Filing Date: 18.07.2000
Chapter 2 Demand Filed: 26.01.2001
IPC:
C07D 207/335 (2006.01) ,C07D 213/38 (2006.01) ,C07D 215/12 (2006.01) ,C07D 233/54 (2006.01) ,C07D 277/28 (2006.01) ,C07D 333/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30
having two double bonds between ring members or between ring members and non-ring members
32
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
33
with substituted hydrocarbon radicals, directly attached to ring carbon atoms
335
Radicals substituted by nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24
with substituted hydrocarbon radicals attached to ring carbon atoms
36
Radicals substituted by singly-bound nitrogen atoms
38
having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
12
with substituted hydrocarbon radicals attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
22
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
28
Radicals substituted by nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
14
Radicals substituted by singly bound hetero atoms other than halogen
20
by nitrogen atoms
Applicants: FINK, Cynthia, Anne[US/US]; US (UsOnly)
KSANDER, Gary, Michael[US/US]; US (UsOnly)
NOVARTIS AG[CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CR, CU, CY, CZ, DE, DK, DM, DZ, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW)
NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.[AT/AT]; Brunner Strasse 59 A-1230 Vienna, AT (AT)
Inventors: FINK, Cynthia, Anne; US
KSANDER, Gary, Michael; US
Agent: BECKER, Konrad; Novartis AG Corporate Intellectual Property Patent & Trademark Department CH-4002 Basel, CH
Priority Data:
09/357,04220.07.1999US
Title (EN) ORGANIC COMPOUNDS
(FR) COMPOSES ORGANIQUES
Abstract:
(EN) Compounds of formula (I) wherein R2-C, R3-C, R4-C or R5-C may be replaced by N; and wherein n is 1, 2 or 3; R1 is carbocyclic aryl or heteroaryl; R2, R3, R4 and R5 are independently hydrogen, lower alkyl, lower alkoxy, halo, trifluoromethyl or cyano; R6 is heteroaryl or heteroaryl-lower alkyl; R7 is hydrogen, lower alkyl or carbocyclic or heterocyclic aryl-lower alkyl; and pharmaceutically acceptable salts thereof; and enantiomers thereof; which are useful as inhibitors of microsomal triglyceride transfer protein (MTP) and of apolipoprotein B (ApoB) secretion and accordingly for the treatment of MTP and Apo B dependent conditions.
(FR) L'invention concerne des composés organiques de formule (I), dans laquelle R2-C, R3-C, R4-C ou R5-C peut être remplacé par N ; et dans laquelle n est 1, 2 ou 3 ; R1 est aryle carbocyclique ou hétéroaryle ; R2, R3, R4 et R5 sont indépendamment hydrogène, alkyle inférieur, alkoxy inférieur, halo, trifluorométhyle ou cyrano ; R6 est hétéroaryle ou hétéroaryle-alkyle inférieur ; R7 est hydrogène, alkyle inférieur ou aryl-alkyle inférieur carbocyclique ou hétérocyclique. La présente invention concerne ces composés, leurs sels acceptables sur le plan pharmaceutique ainsi que leurs énantiomères, qui sont utiles en tant qu'inhibiteurs de la protéine triglycéride transférase microsomique (MTP) et de la sécrétion d'apolipoprotéine B (ApoB). Ainsi, ils sont uégalement utiles pour le traitement des troubles liés à la MTP et à l'Apo B.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)