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1. (WO2001005437) METHODS FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES USING HUMAN MDA-7

Pub. No.:    WO/2001/005437    International Application No.:    PCT/US2000/019392
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Fri Jul 14 01:59:59 CEST 2000
IPC: A61K 48/00
C07K 14/47
Applicants: INTROGEN THERAPEUTICS, INC.
MHASHILKAR, Abner
SCHROCK, Bob
CHADA, Sunil
Inventors: MHASHILKAR, Abner
SCHROCK, Bob
CHADA, Sunil
Title: METHODS FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES USING HUMAN MDA-7
Abstract:
The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed, in one embodiment, to methods for treating a subject with a hyperproliferative disease. In another embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA-7 protein under the control of a promoter operable in eukaryotic cells is administered to the patient with a hyperproliferative disease. The present invention thus provides a gene therapy for treating hyperproliferative disease by elevating the expression of MDA-7 resulting in inhibition of cell growth and induction of apoptosis in hyperproliferative cells.