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1. (WO2001005424) MULTI-COMPONENT VACCINE TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS

Pub. No.:    WO/2001/005424    International Application No.:    PCT/CA2000/000811
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Wed Jul 12 01:59:59 CEST 2000
IPC: A61K 39/116
Applicants: AVENTIS PASTEUR LIMITED
LOOSMORE, Sheena, M.
YANG, Yan-Ping
KLEIN, Michel, H.
SASAKI, Ken
Inventors: LOOSMORE, Sheena, M.
YANG, Yan-Ping
KLEIN, Michel, H.
SASAKI, Ken
Title: MULTI-COMPONENT VACCINE TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS
Abstract:
A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis. Such composition comprises at least four antigens comprising at least one antigen from Haemophilus influenzae, and at least one antigen from Moraxella catarrhalis. Three of the antigens are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of Moraxella catarrhalis comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.