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Machine translation
1. (WO2001005405) FOLYLPOLYGLUTAMYL SYNTHETASE GENE TRANSFER TO ENHANCE ANTIFOLATE DRUG SENSITIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/005405 International Application No.: PCT/US2000/019162
Publication Date: 25.01.2001 International Filing Date: 14.07.2000
Chapter 2 Demand Filed: 14.02.2001
IPC:
A61K 38/00 (2006.01) ,A61K 38/53 (2006.01) ,A61K 45/06 (2006.01) ,A61K 48/00 (2006.01) ,C12N 9/00 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION[US/US]; Fruit Street Boston, MA 02114, US
Inventors: AGHI, Manish; US
KRAMM, Christof, M.; DE
BREAKEFIELD, Xandra, O.; US
Agent: GOLDSTEIN, Jorge, A. ; Sterne, Kessler, Goldstein & Fox P.L.L.C. Suite 600 1100 New York Avenue, N.W. Washington, DC 20005-3934, US
Priority Data:
60/144,07416.07.1999US
Title (EN) FOLYLPOLYGLUTAMYL SYNTHETASE GENE TRANSFER TO ENHANCE ANTIFOLATE DRUG SENSITIVITY
(FR) TRANSFERT DU GENE DE FOLYL-POLYGLUTAMYL SYNTHETASE POUR AMELIORER LA SENSIBILITE AU MEDICAMENTS ANTIFOLIQUES
Abstract:
(EN) Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to polyglutamylatable antifolate drugs, such as methotrexate (MTX) and edatrexate (EDX).
(FR) L'invention concerne des procédés permettant de tuer des cellules néoplastiques, et traite de l'utilisation du transfert du gène de folyl-polyglutamyl synthétase (FPGS) destiné à améliorer la sensibilité de plusieurs types de cellules tumorales à des médicaments antifoliques polyglutamylables, tels que méthotrexate (MTX) et édatrexate (EDX).
Designated States: CA, JP
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)