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1. (WO2001005222) CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 DEFICIENT MICE AND USES THEREOF

Pub. No.:    WO/2001/005222    International Application No.:    PCT/US2000/019371
Publication Date: Fri Jan 26 00:59:59 CET 2001 International Filing Date: Sat Jul 15 01:59:59 CEST 2000
IPC: A61K 38/00
C07K 14/72
C12N 15/85
Applicants: RESEARCH DEVELOPMENT FOUNDATION
Inventors: LEE, Kuo-Fen
BALE, Tracy, L.
SMITH, George, W.
VALE, Wylie
Title: CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 DEFICIENT MICE AND USES THEREOF
Abstract:
The present invention provides transgenic mice deficient in corticotropin releasing factor receptor 2. CRFR2 mutant mice are hypersensitive to stress, and display increased anxiety-like behavior. Mutant mice had normal basal feeding and weight gain, but exhibited decreased food intake following food deprivation. Intravenous UCN has no effect on the mutant mice, but causes decreased arterial pressure in control animals. Deficiency in CRFR2 results in a significant increase in urocortin mRNA in the rostral region of the Edinger Westphal, and a significant increase in CRF mRNA in the central nucleus of the amygdala. These results demonstrate that CRFR2 mutant mice, as opposed to CRFR1 mutant mice, have an increased sensitivity to stress and display anxiety-like behavior.