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1. (WO2001004334) INFECTION WITH CHIMAERIC ADENOVIRUSES OF CELLS NEGATIVE FOR THE ADENOVIRUS SEROTYPE 5 COXSACKI ADENOVIRUS RECEPTOR (CAR)

Pub. No.:    WO/2001/004334    International Application No.:    PCT/NL2000/000481
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Sat Jul 08 01:59:59 CEST 2000
IPC: A61K 48/00
C07K 14/075
C07K 14/705
C12N 5/10
C12N 15/861
Applicants: CRUCELL HOLLAND B.V.
HAVENGA, Menzo
VOGELS, Ronald
Inventors: HAVENGA, Menzo
VOGELS, Ronald
Title: INFECTION WITH CHIMAERIC ADENOVIRUSES OF CELLS NEGATIVE FOR THE ADENOVIRUS SEROTYPE 5 COXSACKI ADENOVIRUS RECEPTOR (CAR)
Abstract:
The invention relates to the field of molecular genetics and medicine. The invention discloses a method for delivering a nucleic acid of interest to a host cell by means of a gene delivery vehicle based on adenoviral material, whereby said gene delivery vehicle delivers the nucleic acid to the host cell by associating with a binding site and/or a receptor present on CAR-negative cells, said binding site and/or receptor being a binding site and/or a receptor for adenovirus subgroups D and/or F.