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1. (WO2001004318) MYXOMA VIRUS GENES FOR IMMUNE MODULATION

Pub. No.:    WO/2001/004318    International Application No.:    PCT/IB2000/001043
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Thu Jul 13 01:59:59 CEST 2000
IPC: A61K 39/00
A61K 48/00
C07K 14/065
Applicants: VIRON THERAPEUTICS, INC.
Inventors: MCFADDEN, Grant
Title: MYXOMA VIRUS GENES FOR IMMUNE MODULATION
Abstract:
The present invention provides genes of the viral genus leporipox that encode immunomodulatory proteins. The present invention also provides therapeutic compositions containing these polypeptides and methods for use for treating a variety of inflammatory and autoimmune disorders. In one preferred embodiment, the present invention provides methods for producing the immunomodulatory polypeptides in a substantially pure form. In another preferred embodiment, the invention provides methods for treating individuals diagnosed with autoimmune or inflammatory disorders by gene therapy. In yet another preferred embodiment, the methods and compositions of the present invention may be used to treat cancer. Finally, the invention provides methods to identify and isolate additional leporipox virus immunomodulatory polypeptides.