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Machine translation
1. (WO2001004309) T-CELL RECEPTOR $g(g) ALTERNATE READING FRAME PROTEIN, (TARP) AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/004309 International Application No.: PCT/US2000/019039
Publication Date: 18.01.2001 International Filing Date: 12.07.2000
Chapter 2 Demand Filed: 08.02.2001
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/47 (2006.01)
Applicants: PASTAN, Ira[US/US]; US (UsOnly)
ESSAND, Magnus[SE/SE]; SE (UsOnly)
LEE, Byungkook[US/US]; US (UsOnly)
VASMATZIS, George[GR/US]; US (UsOnly)
WOLFGANG, Curt[US/US]; US (UsOnly)
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES[US/US]; Bethesda, MD 20892, US (AllExceptUS)
Inventors: PASTAN, Ira; US
ESSAND, Magnus; SE
LEE, Byungkook; US
VASMATZIS, George; US
WOLFGANG, Curt; US
BRINKMANN, Ulrich; DE
Agent: NOONAN, William, D. ; Klarquist Sparkman, LLP One World Trade Center 121 S.W. Salmon Street, Suite 1600 Portland, OR 97204, US
Priority Data:
60/143,56013.07.1999US
60/157,47101.10.1999US
Title (EN) T-CELL RECEPTOR $g(g) ALTERNATE READING FRAME PROTEIN, (TARP) AND USES THEREOF
(FR) PROTEINE CADRE DE LECTURE DE SUBSTITUTION (TARP) DE RECEPTEUR$g(g) DE LYMPHOCYTES T ET SES UTILISATIONS
Abstract:
(EN) This invention provides nucleic acids containing sequences from a TCR$g(g) transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein ('TARP') expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.
(FR) La présente invention concerne des acides nucléiques contenant des séquences provenant d'un transcrit TCR$g(g) de cellules épithéliales de la prostate et de beaucoup de cellules du cancer du sein et une protéine cadre de lecture de substitution (TARP) de récepteur$g(g) de lymphocytes T exprimée par la traduction de ces séquences. Les vaccins fabriqués à partir de TARP conviennent pour augmenter les réponses immunitaires envers des cellules dans lesquelles la protéine est exprimée, y compris les cellules cancéreuses de la prostate et des cellules de nombreux cancers du sein. En outre, cette invention concerne des méthodes permettant de diagnostiquer la présence du cancer de la prostate et des cancers du sein exprimant TARP, ainsi que des méthodes d'administration de TARP et des acides nucléiques codant TARP aux sujets.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)