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1. (WO2001004157) NOVEL METHOD AND COMPOSITION FOR INHIBITION OF ANGIOGENESIS USING ANTAGONISTS BASED ON MMP-9 AND β1 INTEGRINS

Pub. No.:    WO/2001/004157    International Application No.:    PCT/US2000/019095
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Fri Jul 14 01:59:59 CEST 2000
IPC: C07K 16/28
Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventors: BROOKS, Peter, C.
HASSANIEH, Loubna
RODRIGUEZ, Dorothy
Title: NOVEL METHOD AND COMPOSITION FOR INHIBITION OF ANGIOGENESIS USING ANTAGONISTS BASED ON MMP-9 AND β1 INTEGRINS
Abstract:
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiongenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.