WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2001004148) DONOR STRAND COMPLEMENTED PILIN AND ADHESIN BROAD-BASED VACCINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/004148    International Application No.:    PCT/US2000/019066
Publication Date: 18.01.2001 International Filing Date: 13.07.2000
Chapter 2 Demand Filed:    09.02.2001    
IPC:
A61K 39/00 (2006.01), C07K 14/245 (2006.01)
Applicants: MEDIMMUNE, INC. [US/US]; 35 West Watkins Mill Road, Gaithersburg, MD 20878 (US).
WASHINGTON UNIVERSITY [US/US]; 660 South Euclid Avenue, St. Louis, MO 63110 (US)
Inventors: HULTGREN, Scott, J.; (US).
PINKNER, Jerome, S.; (US).
SAUER, Frederic; (US).
BARNHART, Michelle; (US).
WAKSMAN, Gabriel; (US).
KNIGHT, Stefan; (SE)
Agent: GRANT, Alan, J.; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein, 6 Becker Farm Road, Roseland, NJ 07068 (US)
Priority Data:
60/143,582 13.07.1999 US
60/144,359 16.07.1999 US
60/184,442 23.02.2000 US
Title (EN) DONOR STRAND COMPLEMENTED PILIN AND ADHESIN BROAD-BASED VACCINES
(FR) VACCINS DE PILINE ET D'ADHESINE COMPLETES PAR UN BRIN DONNEUR POUR PRODUCTION A GRANDE ECHELLE
Abstract: front page image
(EN)Modified polypeptides containing a pilus-protein sequence and a donor complementary sequence are disclosed, as well as complexes formed of a modified polypeptide and a pilin, or pilus-protein. Also disclosed are methods of using these novel polypeptides as a means of preventing and/or treating bacterial induced diseases, especially those caused by enterobacteria such as Escherichia coli. Methods of employing these modified pilus-derived polypeptides and complexes as vaccines and for generating antibodies for further study as well as for clinical purposes are also disclosed herein. In addition, processes for large scale production of antibacterial vaccines containing said polypeptides and complexes are also described.
(FR)L'invention concerne des polypeptides modifiés contenant une séquence de protéine de pilus et une séquence complémentaire de donneur, ainsi que des complexes constitués d'un polypeptide modifié et d'une piline, ou protéine de pilus. L'invention concerne également des procédés d'utilisation de ces nouveaux polypeptides comme moyen de prévention et/ou de traitement de maladies provoquées par des bactéries, spécialement celles dues à des entérobactéries telles que Escherichia coli. L'invention concerne aussi des procédés d'utilisation de ces polypeptides et complexes dérivés de pilus comme vaccins et pour produire des anticorps en vue d'études ultérieures et à des fins cliniques. De plus, l'invention concerne des procédés de production à grande échelle de vaccins antibactériens contenant lesdits polypeptides et complexes.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)