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|1. (WO2001004135) CROSSLINKED DNA CONDENSATE COMPOSITIONS AND GENE DELIVERY METHODS|
|Applicants:||THE REGENTS OF THE UNIVERSITY OF MICHIGAN
|Inventors:||RICE, Kevin, G.
ADAMI, Roger, C.
MCKENZIE, Donald, L.
COLLARD, Wendy, T.
|Title:||CROSSLINKED DNA CONDENSATE COMPOSITIONS AND GENE DELIVERY METHODS|
Disclosed are improved compositions and methods for use in gene delivery and expression. A range of surprisingly effective cross-linking agents and peptides are provided, as are peptide-DNA carrier compositions and condensed particles with reduced toxicity and increased stability. Advantageous methods of using such compositions in gene delivery and gene expression are further disclosed, which may be used in combination with biocompatible matrices, carriers and/or targeting agents.