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1. (WO2001004135) CROSSLINKED DNA CONDENSATE COMPOSITIONS AND GENE DELIVERY METHODS

Pub. No.:    WO/2001/004135    International Application No.:    PCT/US2000/019164
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Fri Jul 14 01:59:59 CEST 2000
IPC: A61K 47/48
A61K 48/00
C12N 15/87
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: RICE, Kevin, G.
ADAMI, Roger, C.
MCKENZIE, Donald, L.
COLLARD, Wendy, T.
KWOK, Kai
PARK, Youmie
YANG, Yongsheng
Title: CROSSLINKED DNA CONDENSATE COMPOSITIONS AND GENE DELIVERY METHODS
Abstract:
Disclosed are improved compositions and methods for use in gene delivery and expression. A range of surprisingly effective cross-linking agents and peptides are provided, as are peptide-DNA carrier compositions and condensed particles with reduced toxicity and increased stability. Advantageous methods of using such compositions in gene delivery and gene expression are further disclosed, which may be used in combination with biocompatible matrices, carriers and/or targeting agents.