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1. (WO2001004094) PROCESSES FOR THE PREPARATION OF IPIDACRINE OR IPIDACRINE HYDROCHLORIDE HYDRATE

Pub. No.:    WO/2001/004094    International Application No.:    PCT/JP2000/004525
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Fri Jul 07 01:59:59 CEST 2000
IPC: C07D 221/16
Applicants: NIKKEN CHEMICALS CO., LTD.

OMORI, Hiromasa

Inventors: OMORI, Hiromasa

Title: PROCESSES FOR THE PREPARATION OF IPIDACRINE OR IPIDACRINE HYDROCHLORIDE HYDRATE
Abstract:
A process for the preparation of ipidacrine (I) (9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline), which comprises reacting diphosphorus pentaoxide with a trialkyl phosphate and a hydroxyl compound in a hydrocarbon solvent to thereby prepare a polyphosphoric ester having one or more free hydroxyl groups and serving as a dehydrocondensing agent and using this ester without isolation in the condensation of 2-amino-1-cyclopentene-1-carbonitrile with cyclohexanone through dehydration.