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1. (WO2001003731) DIM MUTANTS OF MYCOBACTERIA AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/003731    International Application No.:    PCT/US2000/040312
Publication Date: 18.01.2001 International Filing Date: 06.07.2000
Chapter 2 Demand Filed:    18.12.2000    
IPC:
C07K 14/35 (2006.01)
Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY [US/US]; 1300 Morris Park Avenue, Bronx, NY 10461 (US)
Inventors: COX, Jeffrey, S.; (US).
JACOBS, William, R., Jr.; (US)
Agent: GEORGE, Kenneth, P.; Amster, Rothstein & Ebenstein, 90 Park Avenue, New York, NY 10016 (US).
ARNOLD, Craig, J.; Amster, Rothstein & Ebenstein, 90 Park Avenue, New York, NY 10016 (US)
Priority Data:
09/350,326 09.07.1999 US
Title (EN) DIM MUTANTS OF MYCOBACTERIA AND USES THEREOF
(FR) MUTANTS DIM DE MYCOBACTERIES ET LEURS UTILISATIONS
Abstract: front page image
(EN)Disclosed are novel recombinant mutant strains of mycobacteria that are deficient for the synthesis or transport of dimycoserosalphthiocerol ('DIM'). The present invention also provides a method of producing a recombinant mutant mycobacterium that is deficient for the synthesis or transport of DIM, comprising mutating a nucleic acid responsible for the synthesis or transport of dimycoserosalphthiocerol, including a nucleic acid comprising the promoter for the pps operon, fadD28 or mmpL7. The present invention also provides a vaccine comprising a DIM mutant mycobacterium of the present invention, as well as a method for the treatment or prevention of tuberculosis in a subject using the vaccine.
(FR)L'invention concerne de nouvelles souches mutantes recombinées de mycobactéries insuffisantes pour la synthèse ou le transport de dimycosérolsalphthiocérol (« DIM »). La présente invention concerne aussi une méthode de production d'un mycobactérium mutant recombiné insuffisant pour la synthèse ou le transport de DIM, la méthode consistant à faire muter un acide nucléique responsable de la synthèse ou du transport de dimycosérolsalphthiocérol, y compris un acide nucléique comprenant le promoteur de l'opéron pps, de fadD28 ou de mmpL7. La présente invention concerne en outre un vaccin comprenant un mycobactérium de mutant de DIM selon l'invention, ainsi qu'une méthode de traitement ou de prévention de la tuberculose chez un sujet grâce à ce vaccin.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)