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1. (WO2001003729) RECOMBINANT ENVELOPE VACCINE AGAINST FLAVIVIRUS INFECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/003729 International Application No.: PCT/US2000/018876
Publication Date: 18.01.2001 International Filing Date: 12.07.2000
Chapter 2 Demand Filed: 17.01.2001
IPC:
A61K 39/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
Applicants: IVY, John[--/US]; US (UsOnly)
BIGNAMI, Gary[--/US]; US (UsOnly)
MCDONELL, Michael[--/US]; US (UsOnly)
CLEMENTS, David, E.[--/US]; US (UsOnly)
COLLER, Beth-Ann, G.[--/BE]; BE (UsOnly)
HAWAII BIOTECHNOLOGY GROUP, INC.[US/US]; Suite 236 99-193 Aiea Heights Drive Aiea, HI 96701, US (AllExceptUS)
Inventors: IVY, John; US
BIGNAMI, Gary; US
MCDONELL, Michael; US
CLEMENTS, David, E.; US
COLLER, Beth-Ann, G.; BE
Agent: FAVORITO, Carolyn ; Morrison & Foerster LLP 3811 Valley Centre Drive, Suite 500 San Diego, CA 92130-2332, US
Priority Data:
09/352,38713.07.1999US
Title (EN) RECOMBINANT ENVELOPE VACCINE AGAINST FLAVIVIRUS INFECTION
(FR) VACCIN A ENVELOPPE RECOMBINEE CONTRE LES INFECTIONS A FLAVIVIRUS
Abstract:
(EN) A vaccine contains at least one Drosophila cell-secreted, recombinantly-produced form of a truncated Flavivirus envelope glycoprotein, as an active ingredient, and an adjuvant, as a critical component of the vaccine. The adjuvant is an immunomodulating agent having an iscom-like structure and comprising within the iscom-like structure at least one lipid and at least one saponin, and a pharmaceutically acceptable vehicle. Such a vaccine protects a subject against infection by a Flavivirus.
(FR) Un vaccin contient au moins une forme, sécrétée par des cellules de Drosophila produite par recombinaison, d'une glycoprotéine d'enveloppe tronquée de Flavivirus en tant que principe actif, et un adjuvant, en tant que constituant critique du vaccin. L'adjuvant est un agent immunomodulateur ayant une structure de type iscom et comprenant dans la structure de type iscom au moins un lipide et au moins une saponine, ainsi qu'un excipient acceptable sur le plan pharmaceutique. Un tel vaccin protège un sujet contre une infection par un Flavivirus.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)