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1. (WO2001003702) PHARMACEUTICAL FORMULATIONS COMPRISING A GLUCOCORTICOSTEROID AND AN ANTIFUNGAL AZOLE, FOR INCREASING THE LOCAL MUCOSAL TISSUE CONCENTRATION OF GLUCOCORTICOSTEROIDS IN THE GI TRACT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/003702    International Application No.:    PCT/SE2000/001468
Publication Date: 18.01.2001 International Filing Date: 07.07.2000
Chapter 2 Demand Filed:    21.12.2000    
IPC:
A61K 31/58 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
SEIDEGÅRD, Janeric [SE/SE]; (SE) (For US Only).
BORGÅ, Olof [SE/SE]; (SE) (For US Only)
Inventors: SEIDEGÅRD, Janeric; (SE).
BORGÅ, Olof; (SE)
Agent: GLOBAL INTELLECTUAL PROPERTY, PATENTS; AstraZeneca AB, S-151 85 Södertälje (SE)
Priority Data:
9902675-9 12.07.1999 SE
Title (EN) PHARMACEUTICAL FORMULATIONS COMPRISING A GLUCOCORTICOSTEROID AND AN ANTIFUNGAL AZOLE, FOR INCREASING THE LOCAL MUCOSAL TISSUE CONCENTRATION OF GLUCOCORTICOSTEROIDS IN THE GI TRACT
(FR) FORMULATIONS PHARMACEUTIQUES CONTENANT UN GLUCOCORTICOSTEROIDE ET UN AZOLE ANTIFONGIQUE DESTINEES A AUGMENTER LA CONCENTRATION DANS LES TISSUS MUQUEUX LOCAUX DE GLUCOCORTICOSTEROIDES DANS LES VOIES GI
Abstract: front page image
(EN)The invention relates to pharmaceutical formulations, doses and regimens comprising a glucocorticosteroid and an antifungal azole, which are adapted for administration to the GI mucosal tissue of a patient. The doses and regimens comprise 0.01 to 150 mg of the antifungal azole. The formulation comprises the glucocorticosteroid and antifungal azole in a ratio of 10000:1 to 1:1500 (glucocorticosteroid: antifungal azole). Formulations, doses and regimens of the present invention address the specific problem of increasing the bioavailability of glucocorticosteroids in the GI mucosa of a mammalian patient (e.g. a human), while minimising the potential for liver damage in the patient.
(FR)L'invention concerne des formulations, des doses et des schémas posologiques pharmaceutiques comprenant un glucocorticostéroïde et une azole antifongique, lesquels sont adaptés à une administration aux tissus muqueux GI d'un patient. Les doses et les schémas posologiques comprennent 0,01 à 150 mg de l'azole antifongique. La formulation comprend le glucocorticostéroïde et l'azole antifongique en un rapport de 10000:1 à 1:1500 (glucocorticostéroïde: azole antifongique). Les formulations, les doses et les schémas posologiques de la présente invention traitent du problème spécifique de l'augmentation de la biodisponibilité de glucocorticostéroïdes dans la muqueuse GI d'un patient mammifère (par exemple un sujet humain), tout en réduisant au minimum le potentiel de détérioration du foie du patient.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)