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1. (WO2001003688) TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS

Pub. No.:    WO/2001/003688    International Application No.:    PCT/US2000/040138
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Thu Jun 08 01:59:59 CEST 2000
IPC: A61K 31/201
A61K 31/205
A61K 31/231
A61K 31/28
A61K 31/295
A61K 31/30
A61K 31/315
A61K 38/44
A61K 45/06
Applicants: PHARMACIA CORPORATION
ABBAS, Zaheer
KOBOLDT, Carol
Inventors: ABBAS, Zaheer
KOBOLDT, Carol
Title: TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS
Abstract:
This invention is directed to a process for the prevention or treatment of inflammation or other cyclooxygenase-2 mediated disorders. This process comprises administering a conjugated fatty acid to an organism in an amount effective to prevent or treat the cyclooxygenase-2 mediated disorder by inhibiting cyclooxygenase -2. In one embodiment, the process comprises administering a fatty acid compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; m is from 6 to 11; and the sum of n and m is from 13 to 16. In another embodiment, the process comprises administering a fatty acid compound having formula (VI) or a pharmaceutically acceptable salt thereof, wherein R6 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; R7 is -OH, -SO¿3?H, -SH, -NH2, -PO3H2, or halogen; v is from 7 to 11; and the sum of v and w is from 11 to 15. This invention is also directed to a process for preparing a fatty acid compound. The process comprises combining a ylide with an aldehyde.