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1. (WO2001003659) USE OF RAR ANTAGONISTS AS MODULATORS OF HORMONE MEDIATED PROCESSES

Pub. No.:    WO/2001/003659    International Application No.:    PCT/US2000/018543
Publication Date: Fri Jan 19 00:59:59 CET 2001 International Filing Date: Sat Jul 08 01:59:59 CEST 2000
IPC: A61K 45/06
Applicants: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
Inventors: EVANS, Ronald, M.
TONTONOZ, Peter, J.
NAGY, Laszlo
Title: USE OF RAR ANTAGONISTS AS MODULATORS OF HORMONE MEDIATED PROCESSES
Abstract:
In accordance with the present invention, it has been discovered that retinoic acid receptor (RAR) antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs (e.g., PPARα, PPARδ and PPARη). Indeed, it has been discovered that RAR antagonists, in combination with agonists for members of the steroid/thyroid hormone receptor superfamily, are capable of inducing and/or enhancing processes mediated by such members.