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1. (WO2001002556) AGENTS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MALIGNANT DISEASES

Pub. No.:    WO/2001/002556    International Application No.:    PCT/DE2000/002048
Publication Date: Fri Jan 12 00:59:59 CET 2001 International Filing Date: Sat Jul 01 01:59:59 CEST 2000
IPC: A61K 38/00
A61K 48/00
C07K 14/47
C12N 15/11
Applicants: MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
JÜRCHOTT, Karsten
BERGMANN, Stephan
ROYER, Hans-Dieter
Inventors: JÜRCHOTT, Karsten
BERGMANN, Stephan
ROYER, Hans-Dieter
Title: AGENTS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MALIGNANT DISEASES
Abstract:
The invention relates to agents for the diagnosis, prognosis and treatment of malignant diseases. With the help of the inventive solution, different functions of the YB-1 protein, which plays an important part in the progression of tumours, are inhibited. The proliferation of tumour cells is destroyed by these agents and the cells become sensitive to treatment with known chemotherapeutic agents and can be recognised by the immune system as retrograde. The invention also relates to the detection of YB-1 for use in the diagnosis and prognosis of malignant diseases. The invention further relates to YB-1 peptides, in particular to the N-terminal peptide and mutants and variants of said peptide and other peptides derived from YB-1 which have the same properties and which selectively inhibit tumour cells, in addition to agents for the diagnosis and treatment of malignant diseases which preferably contain these peptides either optionally in combination with each other and/or in combination with additional tumour-inhibitors. In addition, the invention also relates to substances which identify the peptides and influence YB-1. The agents can be used in the medical field and in the pharmaceutical industry.