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1. (WO2001002433) KERATINOCYTE GROWTH FACTOR-2
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/002433 International Application No.: PCT/US2000/018328
Publication Date: 11.01.2001 International Filing Date: 03.07.2000
Chapter 2 Demand Filed: 01.02.2001
IPC:
A61K 38/00 (2006.01) ,C07K 14/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
50
Fibroblast growth factor (FGF)
Applicants:
RUBEN, Steven, M. [US/US]; US (UsOnly)
JIMENEZ, Pablo [US/US]; US (UsOnly)
DUAN, D., Roxanne [US/US]; US (UsOnly)
RAMPY, Mark, A. [US/US]; US (UsOnly)
MENDRICK, Donna [US/US]; US (UsOnly)
ZHANG, Jun [CN/US]; US (UsOnly)
NI, Jian [CN/US]; US (UsOnly)
MOORE, Paul, A. [GB/US]; US (UsOnly)
COLEMAN, Timothy, A. [US/US]; US (UsOnly)
GRUBER, Joachim, R. [DE/US]; US (UsOnly)
DILLON, Patrick, J. [US/US]; US (UsOnly)
GENTZ, Reiner, L. [DE/US]; US (UsOnly)
HUMAN GENOME SCIENCES, INC. [US/US]; 9410 Key West Avenue Rockville, MD 20850, US (AllExceptUS)
Inventors:
RUBEN, Steven, M.; US
JIMENEZ, Pablo; US
DUAN, D., Roxanne; US
RAMPY, Mark, A.; US
MENDRICK, Donna; US
ZHANG, Jun; US
NI, Jian; US
MOORE, Paul, A.; US
COLEMAN, Timothy, A.; US
GRUBER, Joachim, R.; US
DILLON, Patrick, J.; US
GENTZ, Reiner, L.; US
Agent:
STEFFE, Eric, K.; Sterne, Kessler, Goldstein & Fox P.L.L.C. Suite 600 1100 New York Avenue, N.W. Washington, D.C. 20005-3934 , US
Priority Data:
09/610,65130.06.2000US
60/142,34302.07.1999US
60/143,64814.07.1999US
60/144,02415.07.1999US
60/148,62812.08.1999US
60/149,93519.08.1999US
60/163,37503.11.1999US
60/171,67722.12.1999US
60/198,32219.04.2000US
60/205,41719.05.2000US
Title (EN) KERATINOCYTE GROWTH FACTOR-2
(FR) FACTEUR 2 DE CROISSANCE DES KERATINOCYTES
Abstract:
(EN) This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as 'KGF-2' also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
(FR) L'invention concerne: des polynucléotides nouvellement identifiés, des polypeptides codés par ces derniers; l'utilisation de ces polynucléotides et polypeptides; et leur préparation. En particulier, le polypeptide de l'invention est un facteur de croissance des kératinocytes, parfois désigné sous le nom de «KGF-2», comme c'est ici le cas, ou sous le nom de facteur 12 de croissance des fibroblastes (FGF-12). L'invention concerne également l'utilisation thérapeutique du KGF-2 destiné à favoriser ou à accélérer la cicatrisation, ainsi que des nouvelles formes mutantes du KGF-2, qui présentent une activité améliorée, une stabilité accrue, un meilleur rendement ou une meilleure solubilité.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)