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1. (WO2001002428) PROCESS FOR THE PREPARATION OF LH-RH DERIVATIVES

Pub. No.:    WO/2001/002428    International Application No.:    PCT/JP2000/004277
Publication Date: Fri Jan 12 00:59:59 CET 2001 International Filing Date: Fri Jun 30 01:59:59 CEST 2000
IPC: C07K 7/23
Applicants: TAKEDA CHEMICAL INDUSTRIES, LTD.

SASAKI, Yasuhiro

SHIMIZU, Katsuji

Inventors: SASAKI, Yasuhiro

SHIMIZU, Katsuji

Title: PROCESS FOR THE PREPARATION OF LH-RH DERIVATIVES
Abstract:
A process for the preparation of LH-RH derivatives, characterized by subjecting a solution of an LH-RH derivative to both treatment with a synthetic methacrylic resin adsorbent and that with a synthetic aromatic resin adsorbent. According to this process, the formation of by-product impurities including racemates of LH-RH derivatives can be suppressed and such impurities can be efficiently removed, which enables the production of LH-RH derivatives having extremely high quality. Further, the process attains satisfactory purification effectively through the two treatment steps and can give LH-RH derivatives efficiently in high yields by easy operations not involving troublesome solid-liquid separation.