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Machine translation
1. (WO2001002425) PEPTIDE CONJUGATES FOR THE STABILIZATION OF MEMBRANE PROTEINS AND INTERACTIONS WITH BIOLOGICAL MEMBRANES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002425    International Application No.:    PCT/CA2000/000773
Publication Date: 11.01.2001 International Filing Date: 29.06.2000
Chapter 2 Demand Filed:    26.01.2001    
IPC:
C07K 14/00 (2006.01), C07K 14/705 (2006.01)
Applicants: UNIVERSITY HEALTH NETWORK [CA/CA]; University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9 (CA) (For All Designated States Except US).
PRIVE, Gil [CA/CA]; (CA) (For US Only)
Inventors: PRIVE, Gil; (CA)
Agent: VAN ZANT, Joan, M.,; Swabey Ogilvy Renault, Suite 1600, 1981 McGill College Avenue, Montreal, Québec H3A 2Y3 (CA)
Priority Data:
60/140,988 29.06.1999 US
Title (EN) PEPTIDE CONJUGATES FOR THE STABILIZATION OF MEMBRANE PROTEINS AND INTERACTIONS WITH BIOLOGICAL MEMBRANES
(FR) CONJUGUES PEPTIDIQUES FAVORISANT LA STABILISATION DES PROTEINES MEMBRANAIRES ET LES INTERACTIONS AVEC LES MEMBRANES BIOLOGIQUES
Abstract: front page image
(EN)The present invention provides a novel class of detergents referred to herein as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic $g(a)-helical peptide having a hydrophobic or neutral face and a hydrophilic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.
(FR)La présente invention concerne une nouvelle classe de détergents, en l'occurrence des détergents lipopeptides. Ces détergents lipopeptides comprennent un peptide $g(a)-hélicoïdal amphipathique portant une face hydrophobe ou neutre et une face hydrophile. A chaque extrémité de ce peptide se trouve une queue hydrocarbure aliphatique reliée au peptide de façon qu'il s'associe avec la face hydrophobe ou neutre du peptide. De tels détergents lipopeptides conviennent à la stabilisation de protéines membranaires en l'absence d'un bi-couche phospholipide de façon à préserver la conformation d'origine et à en permettre la cristallisation ultérieure.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)