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1. (WO2001002417) NUCLEOTIDE MONOMER CONTAINING SIX-MEMBERED AZARSUGAR AND ANTISENSE OLIGOMERS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002417    International Application No.:    PCT/KR2000/000713
Publication Date: 11.01.2001 International Filing Date: 03.07.2000
Chapter 2 Demand Filed:    02.02.2001    
IPC:
C07H 19/06 (2006.01), C07H 19/10 (2006.01), C07H 19/16 (2006.01), C07H 19/20 (2006.01), C07H 21/00 (2006.01), C12N 15/11 (2006.01)
Applicants: DONGBU HANNONG CHEMICAL CO., LTD. [KR/KR]; 14f, Hankook Joongkongup B/D, #838, Yuksam-dong, Kangnam-ku, Seoul 135-080 (KR) (For All Designated States Except US).
JUNG, Kyeong-Eun [KR/KR]; (KR) (For US Only).
YANG, Mirim [KR/KR]; (KR) (For US Only).
LEE, Kwangjun [KR/KR]; (KR) (For US Only).
KIM, Kichul [KR/KR]; (KR) (For US Only).
LIM, Hong [KR/KR]; (KR) (For US Only)
Inventors: JUNG, Kyeong-Eun; (KR).
YANG, Mirim; (KR).
LEE, Kwangjun; (KR).
KIM, Kichul; (KR).
LIM, Hong; (KR)
Agent: LEE, Won-Hee; 8th Fl., Sung-ji Heights II, 642-16 Yoksam-dong, Kangnam-ku, Seoul 135-080 (KR)
Priority Data:
1999/26947 05.07.1999 KR
Title (EN) NUCLEOTIDE MONOMER CONTAINING SIX-MEMBERED AZARSUGAR AND ANTISENSE OLIGOMERS THEREOF
(FR) MONOMERE NUCLEOTIDIQUE CONTENANT DU SUCRE 'AZAR' EN SIX BRANCHES ET OLIGOMERES ANTISENS DE CE MONOMERE
Abstract: front page image
(EN)The present invention relates to antisense monomers and oligomers which can inhibit transcription for the production of disease-inducing proteins. The antisense monomers and oligomers of the present invention have greater binding affinity for RNA, a target of general antisense medicine, than that for DNA. In addition, they have nuclease resistance, and can improve permeability of cell membrane. The monomers and oligomers of the present invention can be used for antisense therapy inhibiting the expression of disease-inducing genes, hybridization of gene cloning and reagents for diagnosis. They also provide useful tools for the proteins.
(FR)La présente invention concerne des monomères et oligomères antisens capable d'inhiber la transcription destinée à la production de protéines inductrices de maladies. Les monomères et oligomères antisens de l'invention présentent une affinité de liaison plus grande pour l'ARN, une cible des médicaments généraux antisens, que pour l'ADN. En outre, ils présentent une résistance aux nucléases et peuvent améliorer la perméabilité de la membrane de la cellule. Les monomères et oligomères de la présente invention conviennent particulièrement pour la thérapie antisens d'inhibition de l'expression de gènes inducteurs de maladies, pour l'hybridation du clonage génique, et comme réactifs de diagnostic. Ils constituent également des outils utiles pour les protéines.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)