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1. (WO2001002413) BAFIlOMYCIN DERIVATIVES WITH ANTICANCER ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002413    International Application No.:    PCT/GB2000/002511
Publication Date: 11.01.2001 International Filing Date: 30.06.2000
Chapter 2 Demand Filed:    30.01.2001    
IPC:
A61K 31/365 (2006.01), C07D 313/00 (2006.01), C07D 407/06 (2006.01), C07H 17/04 (2006.01), C12P 19/58 (2006.01)
Applicants: INSTITUTO BIOMAR S.A. [ES/ES]; Polig. Industrial, Edificio CEI, Mod. 2.02 y 2.03, Onzonilla, E-24231 Leon (ES) (For All Designated States Except US).
RUFFLES, Graham, Keith [GB/GB]; (GB) (BB only).
PEREZ, Julia [ES/ES]; (ES) (For US Only).
ESPLIEGO, Fernando [ES/ES]; (ES) (For US Only).
GARCIA GRAVALOS, Dolores [ES/ES]; (ES) (For US Only).
MUÑOZ, Alberto [ES/ES]; (ES) (For US Only).
GARCIA, Luis Francisco [ES/ES]; (ES) (For US Only).
CAÑEDO, Librada Maria [ES/ES]; (ES) (For US Only).
ROMERO, Francisco [ES/ES]; (ES) (For US Only)
Inventors: PEREZ, Julia; (ES).
ESPLIEGO, Fernando; (ES).
GARCIA GRAVALOS, Dolores; (ES).
MUÑOZ, Alberto; (ES).
GARCIA, Luis Francisco; (ES).
CAÑEDO, Librada Maria; (ES).
ROMERO, Francisco; (ES)
Agent: RUFFLES, Graham, Keith; Marks & Clerk, 57-60 Lincoln's Inn Fields, London WC2A 3LS (GB)
Priority Data:
9915306.6 30.06.1999 GB
Title (EN) BAFIlOMYCIN DERIVATIVES WITH ANTICANCER ACTIVITY
(FR) DERIVES DE BAFILOMYCINE AYANT UNE ACTION ANTICANCEREUSE
Abstract: front page image
(EN)The invention provides compounds of formula (II), wherein R is -H or -CO-CH=CH-COOH, and pharmaceutically acceptable salts and esters thereof. Processes for the preparation of the compounds, pharmaceutical compositions containing them, and their therapeutic uses are also described. The compounds display activity against tumour growth in mammals. The invention further provides a method for the treatment or prophylaxis of tumour invasion by the administration of compounds of formula (II) or of known macrolide compounds.
(FR)Cette invention a trait à des composés correspondant à la formule (II), dans laquelle R représente H ou CO-CH=CH-COOH, ainsi qu'à leurs sels et esters acceptables du point de vue pharmaceutique. Elle porte également sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques les renfermant ainsi que sur leurs usages thérapeutiques. Ces composés font montre d'une action allant à l'encontre de la croissance de tumeurs chez les mammifères. L'invention concerne, en outre, une méthode de traitement de l'invasion tumorale consistant à administrer des composés correspondant à la formule (II) ou des composés connus de macrolide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)