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1. (WO2001002400) FUSED IMIDAZOLE COMPOUNDS AND REMEDIES FOR DIABETES MELLITUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002400    International Application No.:    PCT/JP2000/004358
Publication Date: 11.01.2001 International Filing Date: 30.06.2000
Chapter 2 Demand Filed:    07.12.2000    
IPC:
C07D 471/04 (2006.01), C07D 473/00 (2006.01), C07D 473/34 (2006.01), C07D 473/40 (2006.01)
Applicants: EISAI CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 112-8088 (JP) (For All Designated States Except US).
ASANO, Osamu [JP/JP]; (JP) (For US Only).
HARADA, Hitoshi [JP/JP]; (JP) (For US Only).
YOSHIKAWA, Seiji [JP/JP]; (JP) (For US Only).
WATANABE, Nobuhisa [JP/JP]; (JP) (For US Only).
INOUE, Takashi [JP/JP]; (JP) (For US Only).
HORIZOE, Tatsuo [JP/JP]; (JP) (For US Only).
YASUDA, Nobuyuki [JP/JP]; (JP) (For US Only).
OOHASHI, Kaya [JP/JP]; (JP) (For US Only).
MINAMI, Hiroe [JP/JP]; (JP) (For US Only).
NAGAOKA, Junsaku [JP/JP]; (JP) (For US Only).
MURAKAMI, Manabu [JP/JP]; (JP) (For US Only).
KOBAYASHI, Seiichi [JP/US]; (US) (For US Only).
TANAKA, Isao [JP/JP]; (JP) (For US Only).
KAWATA, Tsutomu [JP/JP]; (JP) (For US Only).
SHIMOMURA, Naoyuki [JP/JP]; (JP) (For US Only).
AKAMATSU, Hirofumi [JP/JP]; (JP) (For US Only).
OZEKI, Naoki [JP/JP]; (JP) (For US Only).
SHIMIZU, Toshikazu [JP/JP]; (JP) (For US Only).
HAYASHI, Kenji [JP/JP]; (JP) (For US Only).
HAGA, Toyokazu [JP/JP]; (JP) (For US Only).
NEGI, Shigeto [JP/JP]; (JP) (For US Only).
NAITO, Toshihiko [JP/JP]; (JP) (For US Only)
Inventors: ASANO, Osamu; (JP).
HARADA, Hitoshi; (JP).
YOSHIKAWA, Seiji; (JP).
WATANABE, Nobuhisa; (JP).
INOUE, Takashi; (JP).
HORIZOE, Tatsuo; (JP).
YASUDA, Nobuyuki; (JP).
OOHASHI, Kaya; (JP).
MINAMI, Hiroe; (JP).
NAGAOKA, Junsaku; (JP).
MURAKAMI, Manabu; (JP).
KOBAYASHI, Seiichi; (US).
TANAKA, Isao; (JP).
KAWATA, Tsutomu; (JP).
SHIMOMURA, Naoyuki; (JP).
AKAMATSU, Hirofumi; (JP).
OZEKI, Naoki; (JP).
SHIMIZU, Toshikazu; (JP).
HAYASHI, Kenji; (JP).
HAGA, Toyokazu; (JP).
NEGI, Shigeto; (JP).
NAITO, Toshihiko; (JP)
Agent: FURUYA, Kaoru; Hamacho-Hanacho Building, 6th floor, 2-17-8, Nihonbashi-Hamacho, Chuo-ku, Tokyo 103-0007 (JP)
Priority Data:
11/188484 02.07.1999 JP
2000/143495 16.05.2000 JP
2000/182786 19.06.2000 JP
Title (EN) FUSED IMIDAZOLE COMPOUNDS AND REMEDIES FOR DIABETES MELLITUS
(FR) COMPOSES IMIDAZOLE FUSIONNES ET MEDICAMENTS CONTRE LE DIABETE SUCRE
Abstract: front page image
(EN)Novel fused imidazole compounds of general formula (I), pharmacologically acceptable salts thereof, or hydrates of both, exhibiting adenosine A2 receptor antagonism and being effective in the prevention and treatment of diabetes mellitus and complications of diabetes; wherein R1 is optionally alkylated amino or the like; R2 is hydrogen, alkyl, or the like; R3 is optionally substituted aryl, a pyridinone group, a pyrimidinone group, or the like; Ar is an optionally sybstituted aryl or heteroaryl group, or the like; and Q and W are each independently N or CH.
(FR)La présente invention concerne de nouveaux composés imidazole fusionnés représentés par la formule générale (I), certains de leurs sels, hydrates ou ensemble des deux, pharmacologiquement acceptables. Ces composés, qui font preuve d'antagonisme pour le récepteur A2 de l'adénosine, sont indiqués pour la prévention et le traitement du diabète sucré et des complications des diabètes. Dans cette formule, R1 est amino éventuellement alkylé ou analogue, R2 est hydrogène, alkyle ou analogue, R3 est un aryle éventuellement substitué, un groupe pyridinone, un groupe pyrimidinone ou analogue, Ar est un groupe aryle ou hétéroaryle éventuellement substitué, ou analogue, et A et W sont chacun indépendamment N ou CH.
Designated States: AU, BR, CA, CN, HU, IL, JP, KR, MX, NO, NZ, RU, US, ZA.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)