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1. (WO2001002394) SUBSTITUTED INDOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002394    International Application No.:    PCT/US2000/018112
Publication Date: 11.01.2001 International Filing Date: 30.06.2000
IPC:
A61K 31/426 (2006.01), A61K 31/4439 (2006.01), A61K 31/506 (2006.01), C07D 277/34 (2006.01), C07D 277/36 (2006.01), C07D 417/06 (2006.01), C07D 417/10 (2006.01), C07D 513/04 (2006.01)
Applicants: GERON CORPORATION [US/US]; 230 Constitution Drive, Menlo Park, CA 94025 (US) (For All Designated States Except US).
CHIN, Allison, C. [US/US]; (US) (For US Only).
TOLMAN, Richard, L. [US/US]; (US) (For US Only).
NGUYEN, Mark, Q. [US/US]; (US) (For US Only).
HOLCOMB, Ryan [US/US]; (US) (For US Only)
Inventors: CHIN, Allison, C.; (US).
TOLMAN, Richard, L.; (US).
NGUYEN, Mark, Q.; (US).
HOLCOMB, Ryan; (US)
Agent: EARP, David, J.; Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025 (US)
Priority Data:
60/142,173 01.07.1999 US
Title (EN) SUBSTITUTED INDOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER
(FR) COMPOSES INDOLE SUBSTITUES ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
(FR)L'invention porte sur des composés de 5-(3-Isatinylidinyl)thiazolidineones et de 3-(thiazolidinon-5-yl)indoles, sur des compositions et sur des procédés d'inhibition de l'activité de la télomérase in vitro et de traitement des états ou pathologies induits par la télomérase ex vivo et in vivo. Ces procédés, composés et compositions peuvent être employés seuls, ou en combinaison avec d'autres agents actifs d'un point de vue pharmacologique, dans le traitement d'états ou pathologies induits par l'activité de la télomérase tel que le traitement du cancer. L'invention porte également sur de nouveaux procédés de dosage ou de recherche systématique d'inhibiteurs de l'activité de la télomérase.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)