Search International and National Patent Collections

1. (WO2001002377) TELOMERASE INHIBITORS AND METHODS OF THEIR USE

Pub. No.:    WO/2001/002377    International Application No.:    PCT/US2000/018211
Publication Date: Fri Jan 12 00:59:59 CET 2001 International Filing Date: Sat Jul 01 01:59:59 CEST 2000
IPC: A61K 31/426
A61K 31/4439
A61K 31/506
C07D 277/34
C07D 277/36
C07D 417/06
C07D 417/10
C07D 513/04
Applicants: GERON CORPORATION
KYOWA HAKKO KOGYO CO., LTD.
CHIN, Allison, C.
HOLCOMB, Ryan
PIATYSZEK, Mieczyslaw, A.
SINGH, Upinder
TOLMAN, Richard, L.
AKAMA, Tsutomu
KANDA, Yutaka
ASAI, Akira
YAMASHITA, Yoshinori
ENDO, Kaori
YAMAGUCHI, Hiroyuki
Inventors: CHIN, Allison, C.
HOLCOMB, Ryan
PIATYSZEK, Mieczyslaw, A.
SINGH, Upinder
TOLMAN, Richard, L.
AKAMA, Tsutomu
KANDA, Yutaka
ASAI, Akira
YAMASHITA, Yoshinori
ENDO, Kaori
YAMAGUCHI, Hiroyuki
Title: TELOMERASE INHIBITORS AND METHODS OF THEIR USE
Abstract:
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatmnet of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.