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1. (WO2001002369) INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/002369 International Application No.: PCT/US2000/018263
Publication Date: 11.01.2001 International Filing Date: 30.06.2000
Chapter 2 Demand Filed: 02.01.2001
IPC:
C07D 209/18 (2006.01) ,C07D 231/56 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/06 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/04 (2006.01) ,C07D 403/12 (2006.01) ,C07D 403/14 (2006.01) ,C07D 405/06 (2006.01) ,C07D 405/14 (2006.01) ,C07D 409/06 (2006.01) ,C07D 409/12 (2006.01) ,C07D 409/14 (2006.01) ,C07D 413/12 (2006.01) ,C07D 417/12 (2006.01) ,C07D 417/14 (2006.01) ,C07D 471/04 (2006.01)
Applicants: AGOURON PHARMACEUTICALS, INC.[US/US]; 10350 North Torrey Pines Road La Jolla, CA 92037-1020, US
Inventors: KANIA, Robert, Steven; US
BENDER, Steven, Lee; US
BORCHARDT, Allen, J.; US
BRAGANZA, John, F.; US
CRIPPS, Stephan, James; US
HUA, Ye; US
JOHNSON, Michael, David; US
JOHNSON, Theodore, Otto, Jr.; US
LUU, Hiep, The; US
PALMER, Cynthia, Louise; US
REICH, Siegfried, Heinz; US
TEMPCZYK-RUSSELL, Anna, Maria; US
TENG, Min; US
THOMAS, Christine; US
VARNEY, Michael, David; US
WALLACE, Michael, Brennan; US
COLLINS, Michael, Raymond; US
Agent: PINO, Mark, J.; Shanks & Herbert TransPotomac Plaza 1033 North Fairfax Street Suite 306 Alexandria, VA 22314 , US
Priority Data:
60/142,13002.07.1999US
Title (EN) INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE
(FR) COMPOSES D'INDAZOLE ET COMPOSITIONS PHARMACEUTIQUES INHIBANT LES PROTEINES KINASES, ET PROCEDES D'UTILISATION DE CEUX-CI
Abstract: front page image
(EN) Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
(FR) L'invention concerne des composés d'indazole qui modulent et/ou inhibent l'activité de certaines protéines kinases. Ces composés et les compositions pharmaceutiques qui les contiennent sont capables d'intervenir dans la transduction du signal de tyrosine kinase, et de moduler et/ou d'inhiber de cette manière une prolifération cellulaire indésirable. L'invention a également trait à l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant ces composés, et à des méthodes de traitement du cancer et d'autres affections associées à une angiogenèse et/ou à une prolifération cellulaire indésirables, telles que la rétinopathie diabétique, le glaucome néovasculaire, la polyarthrite rhumatoïde et le psoriasis, par l'administration de quantités efficaces de ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)