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1. (WO2001002352) CRYSTALLINE 1$g(a),24(S)-DIHYDROXYVITAMIN D2 AND METHOD OF PURIFICATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002352    International Application No.:    PCT/US2000/014494
Publication Date: 11.01.2001 International Filing Date: 24.05.2000
Chapter 2 Demand Filed:    22.01.2001    
IPC:
C07C 401/00 (2006.01)
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 North Walnut St, Madison, WI 53705 (US)
Inventors: DELUCA, Hector, F.; (US).
SICINSKI, Rafal, R.; (US).
HOLDEN, Hazel; (US).
THODEN, James, Brian; (US)
Agent: WOZNY, Thomas, M.; Andrus, Sceales, Starke & Sawall, LLP, Suite 1100, 100 East Wisconsin Avenue, Milwaukee, WI 53202 (US).
ELLIS-JOPNES, Patrick George Armine J.A. KEMP & CO.,; 14 South Square,, Gray's Inn,, London, WC1R 5LX (GB)
Priority Data:
60/141,967 01.07.1999 US
09/437,307 10.11.1999 US
Title (EN) CRYSTALLINE 1$g(a),24(S)-DIHYDROXYVITAMIN D2 AND METHOD OF PURIFICATION THEREOF
(FR) 1$g(a),24(S)-DIHYDROXYVITAMINE D2 CRISTALLINE ET PROCEDE DE PURIFICATION ASSOCIE
Abstract: front page image
(EN)A method of purifying 1$g(a),24(S)-dihydroxyvitamin D2 to obtain 1$g(a),24(S)-dihydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent under inert atmosphere, dissolving a product containing 1$g(a),24(S)-dihydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1$g(a),24(S)-dihydroxyvitamin D2 crystals, and recovering the 1$g(a),24(S)-dihydroxyvitamin D2 crystals. The purification technique involves using one of several binary solvent systems, namely, acetone and hexane, 2-propanol and hexane, or ethyl formate and petroleum ether.
(FR)La présente invention concerne un procédé de purification de 1$g(a),24(S)-dihydroxyvitamine D2 afin d'obtenir de la 1$g(a),24(S)-dihydroxyvitamine D2 sous forme cristalline. Le procédé consiste à faire bouillir un solvant sous atmosphère inerte, à dissoudre dans ce solvant, aux fins de purification, un produit contenant de la 1$g(a),24(S)-dihydroxyvitamine D2, à refroidir le solvant et le produit dissous à une température inférieure à l'ambiante pendant une durée suffisante afin de former un précipité de cristaux de 1$g(a),24(S)-dihydroxyvitamine D2, et à récupérer les cristaux de 1$g(a),24(S)-dihydroxyvitamine D2. Cette technique de purification met en oeuvre l'utilisation d'un ou plusieurs systèmes de solvants binaires, principalement, acétone et hexane, 2-propanol et hexane, ou formiate d'éthyle et éther de pétrole.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)