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1. (WO2001002349) PHENYL SULFAMATE DERIVATIVES

Pub. No.:    WO/2001/002349    International Application No.:    PCT/JP2000/004427
Publication Date: Fri Jan 12 00:59:59 CET 2001 International Filing Date: Wed Jul 05 01:59:59 CEST 2000
IPC: C07C 307/02
C07D 213/30
C07D 213/74
C07D 213/82
C07D 239/42
C07D 241/20
C07D 277/24
C07D 333/20
C07D 333/38
C07D 521/00
Applicants: TEIKOKU HORMONE MFG. CO., LTD.

KOIZUMI, Naoyuki

OKADA, Makoto

IWASHITA, Shigeki

TAKEGAWA, Shigehiro

NAKAGAWA, Takayoshi

TAKAHASHI, Hiroo

FUJII, Tomohito

Inventors: KOIZUMI, Naoyuki

OKADA, Makoto

IWASHITA, Shigeki

TAKEGAWA, Shigehiro

NAKAGAWA, Takayoshi

TAKAHASHI, Hiroo

FUJII, Tomohito

Title: PHENYL SULFAMATE DERIVATIVES
Abstract:
Phenyl sulfamate derivatives of general formula (I) or salts thereof, exhibiting an excellent steroid sulfatase inhibitory activity and being therefore effective in the prevention or treatment of diseases related to steroids including estrogen, e.g., mammary carcinoma, carcinoma of uterine body, endometrial hyperplasia, sterility, endometriosis, adenomyosis of uterus, autoimmune diseases, dementia, Alzheimer's disease and so on, wherein R?1 and R2¿ are each independently hydrogen or lower alkyl; R3 is hydrogen, halogeno, lower alkyl, -OSO¿2NR?1R2, lower alkanoylamino, nitro, or cyano; and A is substituted or unsubstituted phenyl, -X-NR4R5, or the like.