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1. (WO2001002344) AMINOBENZOIC ACID DERIVATIVES

Pub. No.:    WO/2001/002344    International Application No.:    PCT/JP2000/004406
Publication Date: Fri Jan 12 00:59:59 CET 2001 International Filing Date: Tue Jul 04 01:59:59 CEST 2000
IPC: C07C 235/24
C07C 235/38
C07C 317/50
C07C 323/63
C07D 213/80
Applicants: TAISHO PHARMACEUTICAL CO., LTD.

WADA, Hisaya

ASANUMA, Hajime

TAKAYAMA, Tetsuo

SATO, Masakazu

YAMAGISHI, Takehiro

SHIBUYA, Masabumi

Inventors: WADA, Hisaya

ASANUMA, Hajime

TAKAYAMA, Tetsuo

SATO, Masakazu

YAMAGISHI, Takehiro

SHIBUYA, Masabumi

Title: AMINOBENZOIC ACID DERIVATIVES
Abstract:
Aminobenzoic acid derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof which are usable as VEGF receptor antagonists, in particular, remedies for diseases in which VEGF participates wherein R1 represents hydrogen, C¿1-6? alkyl, etc.; R?2¿ represents hydrogen, C¿1-6? alkyl, etc.; R?3¿ represents C¿8-25? alkyl, etc.; R?4¿ represents hydrogen, OR9 or CO¿2R?10 (wherein R?9 and R10¿ represent each hydrogen or C¿1-6? alkyl); A represents S(O)qR?15¿ [wherein q is 0, 1 or 2; and R15 represents C¿1-6? alkyl, phenyl (C1-3 alkyl) or (CH2)mOR?16¿ (wherein m is 2 or 3; and R16 represents hydrogen or methoxymethyl)], etc.; X represents O, a single bond, CH=CH or NR27 (wherein R27 represents hydrogen or t-butoxycarbonyl); Y represents O, CONH, NHCO or NR28 (wherein R28 represents hydrogen or t-butoxycarbonyl); and n is an integer of from 0 to 15.