US2000017606 TARGETED ANTICALCIFICATION TREATMENT

1. (WO2001002031) TARGETED ANTICALCIFICATION TREATMENT

National Phase

Notices

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Latest bibliographic data on file with the International Bureau

Pub. No.:	WO/2001/002031	International Application No.:	PCT/US2000/017606
Publication Date:	11.01.2001	International Filing Date:	27.06.2000
Chapter 2 Demand Filed:	26.01.2001

IPC:

A61L 27/50 (2006.01)

Applicants:

BIOMEDICAL DESIGN, INC. [US/US]; 2161 New Market Parkway, S.E., Suite 214, Marietta, GA 30067-9310 (US)

Inventors:

SIMIONESCU, Dan; (US).
SIMIONESCU, Agneta; (RO).
GIRARDOT, Jean-Marie; (US).
GIRARDOT, Marie-Nadia; (US)

Agent:

SAMPLES, Kenneth, H.; Fitch, Even, Tabin & Flannery, Suite 1600, 120 South LaSalle, Chicago, IL 60603 (US)

Priority Data:

60/142,171

01.07.1999

Title

(EN) TARGETED ANTICALCIFICATION TREATMENT
(FR) TRAITEMENT ANTI-CALCIFICATION CIBLE

Abstract:

(EN)Methods for providing biomaterials with increased resistance to calcification by treating with cell-targeted agents and/or with matrix-targeted agents. Cell-targeted agents are used which block calcium channels or which prevent oxidative damage to cells and/or inhibit enzymes. Other treatments of biomaterials may remove cell-derived calcium-binding components or target extracellular matrices, as by cleaving proteins with cyanogen bromide or reducing disulfide bonds to produce sulfhydryl groups which are thereafter alkylated. Combinations of the foregoing different treatments are also effective in increasing the calcification resistance of cardiovascular tissues that were previously subjected to chemical fixing and/or other anticalcification treatments.
(FR)La présente invention concerne des procédés permettant de conférer aux biomatériaux une résistance accrue à la calcification, grâce à un traitement au moyen d'agents à ciblage cellulaire et/ou à ciblage matriciel. En l'occurrence, on utilise des agents à ciblage cellulaire qui bloquent les canaux calcium, ou qui préviennent l'atteinte oxydative des cellules, et/ou qui inhibent des enzymes. D'autres traitements des biomatériaux permettent d'éliminer des composants de liaison au calcaire issus des cellules, ou cibler des matrices extracellulaire, notamment par un clivage de protéines au moyen du bromure de cyanogène, ou par réduction des liaisons bisulfure donnant des groupes sulfhydryles qui sont ensuite alkylés. Différentes combinaisons de ces traitements permettent également d'augmenter la résistance à la calcification de tissus cardio-vasculaires ayant préalablement subi des traitements de fixation chimique ou d'anti-calcification.

Designated States:

AU, CA, JP.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).

Publication Language:	English (EN)
Filing Language:	English (EN)

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