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1. (WO2001002015) COMPOSITION AND METHOD FOR ENHANCED TRANSDERMAL ABSORPTION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/002015    International Application No.:    PCT/US2000/009242
Publication Date: 11.01.2001 International Filing Date: 06.04.2000
Chapter 2 Demand Filed:    30.01.2001    
IPC:
A61K 31/00 (2006.01), A61K 31/167 (2006.01), A61K 31/192 (2006.01), A61K 31/196 (2006.01), A61K 31/381 (2006.01), A61K 31/40 (2006.01), A61K 31/405 (2006.01), A61K 31/4152 (2006.01), A61K 31/436 (2006.01), A61K 31/439 (2006.01), A61K 31/48 (2006.01), A61K 31/53 (2006.01), A61K 31/5415 (2006.01), A61K 47/10 (2006.01), A61K 47/14 (2006.01), A61K 47/18 (2006.01)
Applicants: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US/US]; 632 Boyd Graduate Studies Research Center, Athens, GA 30602-7411 (US)
Inventors: JUN, H., Won; (US).
KANG, Lisheng; (US)
Agent: SANDBERG, Victoria, A.; Mueting, Raasch & Gebhardt, P.A., P.O. Box 581415, Minneapolis, MN 55458-1415 (US)
Priority Data:
09/346,187 01.07.1999 US
Title (EN) COMPOSITION AND METHOD FOR ENHANCED TRANSDERMAL ABSORPTION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
(FR) COMPOSITION ET METHODE D'ABSORPTION TRANSDERMIQUE AMELIOREE D'ANTI-INFLAMMATOIRES NON STEROIDIENS
Abstract: front page image
(EN)A novel topical formulation for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) is characterized by enhanced transdermal absorption and efficacy. A two phase liquid composition has aqueous and oil phases, the oil phase having a relatively high concentration of the NSAID to enhance transdermal absorption and efficacy when incorporated into the topical anti-inflammatory formulation. The two phase liquid composition preferably contains, in addition to an NSAID, at least one melting point depressing agent. A preferred topical anti-inflammatory composition includes S(+)-ibuprofen, thymol, and ethyl alcohol or isopropyl alcohol.
(FR)Une nouvelle formulation à usage local d'administration d'anti-inflammatoires non stéroïdiens (AINS) est caractérisée par une absorption et une efficacité transdermiques améliorées. Une composition liquide à deux phases comprend des phases aqueuse et huileuse, la phase huileuse ayant une concentration relativement élevée d'AINS afin d'améliorer l'absorption et l'efficacité transdermique lorsqu'elle est incorporée à la formulation anti-inflammatoire à usage local. La composition liquide à deux phases contient de préférence, en plus d'un AINS, au moins un agent abaissant le point de fusion. La composition anti-inflammatoire préférée à usage local contient du S(+)-ibuprofène, du thymol ainsi qu'un alcool éthylique ou un alcool isopropylique.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)