Search International and National Patent Collections

1. (WO2001002004) PERITONEAL DIALYSIS SOLUTION CONTAINING ANTIOXIDANT FOR TREATING RENAL FAILURE

Pub. No.:    WO/2001/002004    International Application No.:    PCT/KR2000/000654
Publication Date: Fri Jan 12 00:59:59 CET 2001 International Filing Date: Thu Jun 22 01:59:59 CEST 2000
IPC: A61K 38/44
A61M 1/28
Applicants: LEE, Hi Bahl
HA, Hunjoo
KIM, Sungil
Inventors: LEE, Hi Bahl
HA, Hunjoo
KIM, Sungil
Title: PERITONEAL DIALYSIS SOLUTION CONTAINING ANTIOXIDANT FOR TREATING RENAL FAILURE
Abstract:
The present invention relates to peritoneal dialysis solutions containing antioxidant(s) for patients with end-stage renal failure undergoing peritoneal dialysis. More specifically, the present invention relates to peritoneal dialysis solutions containing electrolyte (Na+, Mg2+, Ca2+ and C1-), buffer (lactate and/or bicarbonate), osmotic agent(s) (glucose, polyglucose, amino acid, glycerol, polypeptide, or combinations thereof) and antioxidant(s) (catalase, taurine, ascorbic acid, α-tocopherol, N-acetylcysteine, glutathione, α-lipoic acid, superoxide dismutase, or combinations thereof) that inhibits reactive oxygen species. By inhibiting reactive oxygen species that may be generated by the stimulation of high concentration of glucose contained in peritoneal dialysis solutions, the peritoneal dialysis solution of the present invention, unlike the currently used peritoneal dialysis solutions, can prevent oxidative stress and subsequent peritoneal injury.