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1. (WO2001001966) SUSTAINED RELEASE DOSAGE FORM UNIT HAVING LATEX COATING AND METHOD OF MAKING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/001966 International Application No.: PCT/US2000/017796
Publication Date: 11.01.2001 International Filing Date: 28.06.2000
Chapter 2 Demand Filed: 20.01.2001
IPC:
A61K 9/20 (2006.01) ,A61K 9/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
Applicants:
ABBOTT LABORATORIES [US/US]; Dept. 377/ AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-6050, US
Inventors:
MAZER, Terry, B.; US
WALTON, Joseph, E.; US
ARNHOLT, Barbara, S.; US
EVANS, Monty, L.; US
GECKLE, Ronita, K.; US
HAMILTON, Daniel; US
KROPCZYNSKI, John, J., Jr.; US
MURAWSKI, Franka, A.; US
TUCKER, Larry, G.; US
WALKER, Sherri, A.; US
WALSH, Michael, V.; US
WALSH, Rhonda, E.; US
Agent:
WEINSTEIN, David, L. ; Dept. 377, AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-6050, US
Priority Data:
09/345,91501.07.1999US
Title (EN) SUSTAINED RELEASE DOSAGE FORM UNIT HAVING LATEX COATING AND METHOD OF MAKING THE SAME
(FR) FORME POSOLOGIQUE A LIBERATION CONTINUE A ENROBAGE DE LATEX ET SON PROCEDE DE REALISATION
Abstract:
(EN) Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.
(FR) L'invention porte sur une forme posologique servant à administrer un ou plusieurs agents bénéfiques tels que des liquide entéral nutritionnel. Le noyau de ladite forme contient au moins un agent bénéfique, de préférence un colorant marqueur dispersé dans le liquide le noyau contient de plus un agent liant ensemble les agents bénéfiques. Ainsi que des additifs tels que des plastifiants, un fluidifiant courant, un lubrifiant, des aides additionnels à l'enrobage, et au moins un agent hydrophile. Le noyau est enrobé d'une composition de latex comprenant un matériau de base sensiblement hydrophile, de préférence constitué d'une émulsion de microsphères d'acétate de cellulose pouvant former une membrane du type matrice, et au moins un composant hydrophile dispersible dans le liquide. On préfère intégrer un agent bénéfique à l'enrobage de latex pour en assurer la libération immédiate. L'invention porte également sur un procédé de réalisation de ladite forme posologique dispersible.
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Designated States: AU, CA, JP, MX, NO, NZ
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)